Effects of an attachment-based intervention on autonomic regulation among opioid-exposed infants.
Effects of an attachment-based intervention on autonomic regulation among opioid-exposed infants.
复制标题
DOI：
10.1002/dev.22286
复制
发表时间：
2022-09
影响因子：
2.2
通讯作者：
中科院分区：
文献类型：
--
作者：
对于因产前阿片类药物暴露而面临失调风险的婴儿，产后干预是否能增强自主神经调节尚不清楚。本研究在一项试点随机临床试验中评估了改良依恋行为追赶 (mABC) 对阿片类药物暴露婴儿自主调节的影响。我们假设，与对照干预措施（改良的家庭发展教育 [mDEF]）相比，mABC 与较高的静息呼吸性窦性心律失常 (RSA) 和射血前期 (PEP) 以及对社会压力源的更大反应和恢复有关（静止面孔范式）。接受阿片类激动剂治疗的孕妇或围产期妇女（61 名母亲，64 名婴儿；最终 N = 36 名婴儿）被随机分配至 mABC 或 mDEF，从妊娠晚期开始进行 12 次家访计划； mABC 针对敏感的育儿方式，mDEF 针对认知和运动发展。 mABC 与显着较高的 RSA 反应性和略微较高的 PEP 反应性相关。在容纳缺失数据的模型中，mABC 还与显着更高的 RSA 恢复相关。在排除兄弟姐妹的敏感性分析中，mABC 预测 PEP 反应性显着增强。总体而言，在这些初步分析中，与 mDEF 相比，mABC 在社会压力源期间与更健康的自主调节相关。因此，mABC 可能是一种通过育儿干预促进阿片类药物暴露婴儿自主调节的有前途的策略。
Little is known about whether postnatal intervention enhances autonomic regulation among infants at risk for dysregulation due to prenatal opioid exposure. The present study evaluated the effects of modified Attachment Behavioral Catch-up (mABC) on autonomic regulation for opioid-exposed infants in a pilot randomized clinical trial. We hypothesized that, compared to a control intervention (modified Developmental Education for Families [mDEF]), mABC would be associated with higher resting respiratory sinus arrhythmia (RSA) and pre-ejection period (PEP) as well as greater reactivity to and recovery from a social stressor (Still-Face Paradigm). Pregnant or peripartum women receiving opioid agonist therapy (61 mothers of 64 infants; final N = 36 infants) were randomly assigned to mABC or mDEF, 12-session home visiting programs beginning in the third trimester; mABC targets sensitive parenting, and mDEF targets cognitive and motor development. mABC was associated with significantly greater RSA reactivity and marginally greater PEP reactivity. In models accommodating missing data, mABC was additionally associated with significantly greater RSA recovery. In sensitivity analyses removing siblings, mABC predicted significantly enhanced PEP reactivity. Overall, in these preliminary analyses, mABC was associated with healthier autonomic regulation during a social stressor than mDEF. Thus, mABC may be a promising strategy to promote autonomic regulation among opioid-exposed infants through parenting intervention.
登录
查看更多内容
影响因子：
4.6
作者：
Bernard K;Dozier M;Bick J;Lewis-Morrarty E;Lindhiem O;Carlson E
通讯作者：
Carlson E
影响因子：
3.8
作者：
Labella MH;Eiden RD;Roben CKP;Dozier M
通讯作者：
Dozier M
影响因子：
2.2
作者：
Flykt, Marjo Susanna;Lindblom, Jallu;Punamaki, Raija-Leena
通讯作者：
Punamaki, Raija-Leena
影响因子：
5.9
作者：
Beauchaine, Theodore P
通讯作者：
Beauchaine, Theodore P
影响因子：
10.6
作者：
Bick, Johanna;Palmwood, Erin N.;Dozier, Mary
通讯作者：
Dozier, Mary