Coming of Age: CD96 Emerges as Modulator of Immune Responses.
Coming of Age: CD96 Emerges as Modulator of Immune Responses.
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DOI：
10.3389/fimmu.2018.01072
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发表时间：
2018
影响因子：
7.3
通讯作者：
Bernhardt G
中科院分区：
文献类型：
--
作者：
Georgiev H;Ravens I;Papadogianni G;Bernhardt G
CD96代表属于免疫球蛋白超家族的I型跨膜糖蛋白。CD96主要由造血来源的细胞表达，特别是在T和NK细胞上。在与靶细胞上存在的CD155相互作用后，发现CD96抑制小鼠NK细胞，并且通过用抗体阻断或敲除CD96而不存在这种相互作用显示出在鼠模型系统中抑制肿瘤和转移性扩散的显著有益作用。然而，我们对CD 96功能的了解仍然不完整。在这篇综述中，我们将讨论CD96的结构特征及其对功能的影响，以及一些尚未解决的问题，如可能由人而不是小鼠CD96赋予的潜在激活。这对于转化为人类癌症治疗具有重要意义。我们还将在由CD155、CD96、CD226和TIGIT组成的免疫调节网络的背景下讨论CD96活性。
CD96 represents a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD96 is expressed mainly by cells of hematopoietic origin, in particular on T and NK cells. Upon interaction with CD155 present on target cells, CD96 was found to inhibit mouse NK cells, and absence of this interaction either by blocking with antibody or knockout of CD96 showed profound beneficial effects in containment of tumors and metastatic spread in murine model systems. However, our knowledge regarding CD96 functions remains fragmentary. In this review, we will discuss structural features of CD96 and their putative impact on function as well as some unresolved issues such as a potential activation that may be conferred by human but not mouse CD96. This is of importance for translation into human cancer therapy. We will also address CD96 activities in the context of the immune regulatory network that consists of CD155, CD96, CD226, and TIGIT.
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