Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.
Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.
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DOI：
10.1016/j.radonc.2016.06.017
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
International Radiogenomics Consortium (RgC)
中科院分区：
文献类型：
--
作者：
Andreassen CN;Rosenstein BS;Kerns SL;Ostrer H;De Ruysscher D;Cesaretti JA;Barnett GC;Dunning AM;Dorling L;West CML;Burnet NG;Elliott R;Coles C;Hall E;Fachal L;Vega A;Gómez-Caamaño A;Talbot CJ;Symonds RP;De Ruyck K;Thierens H;Ost P;Chang-Claude J;Seibold P;Popanda O;Overgaard M;Dearnaley D;Sydes MR;Azria D;Koch CA;Parliament M;Blackshaw M;Sia M;Fuentes-Raspall MJ;Ramon Y Cajal T;Barnadas A;Vesprini D;Gutiérrez-Enríquez S;Mollà M;Díez O;Yarnold JR;Overgaard J;Bentzen SM;Alsner J;International Radiogenomics Consortium (RgC)
几项小型研究表明，ATM rs1801516 SNP与放射治疗后正常组织毒性风险相关。然而，研究结果并不一致。为了在一项强有力的研究中测试该SNP，国际放射基因组学联盟进行了一项个体患者数据荟萃分析。该分析包括来自17个不同队列的5456名患者。2759例乳腺癌患者接受放疗，2697例前列腺癌患者接受放疗。分析8项毒性评分（总毒性、急性毒性、晚期毒性、急性皮肤毒性、急性直肠毒性、毛细血管扩张、纤维化和直肠晚期毒性）。对可能影响毒性风险的治疗和患者相关因素进行了调整。在除直肠晚期毒性外的所有终点，发现小等位基因（Asn）携带者的毒性风险显著增加，急性毒性的比值比约为1.5，晚期毒性的比值比约为1.2。结果与共显性遗传模式一致。该研究令人信服地表明，ATM rs1801516 Asn等位基因与辐射诱导的正常组织毒性风险增加之间存在显著关联。
Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium. The analysis included 5456 patients from 17 different cohorts. 2759 patients were given radiotherapy for breast cancer and 2697 for prostate cancer. Eight toxicity scores (overall toxicity, acute toxicity, late toxicity, acute skin toxicity, acute rectal toxicity, telangiectasia, fibrosis and late rectal toxicity) were analyzed. Adjustments were made for treatment and patient related factors with potential impact on the risk of toxicity. For all endpoints except late rectal toxicity, a significantly increased risk of toxicity was found for carriers of the minor (Asn) allele with odds ratios of approximately 1.5 for acute toxicity and 1.2 for late toxicity. The results were consistent with a co-dominant pattern of inheritance. This study convincingly showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.
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影响因子：
5.7
作者：
Barnett, Gillian C.;Elliott, Rebecca M.;Bentzen, Soren M.
通讯作者：
Bentzen, Soren M.
影响因子：
50.5
作者：
Bourgier, C.;Kerns, S.;Azria, D.
通讯作者：
Azria, D.
影响因子：
2.6
作者：
Andreassen, C. N.;Alsner, J.;Overgaard, J.
通讯作者：
Overgaard, J.
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
DOI：
10.1016/j.ijrobp.2012.08.003
发表时间：
2013-01-01
影响因子：
7
作者：
Kerns, Sarah L.;Stock, Richard;Stone, Nelson;Buckstein, Michael;Shao, Yongzhao;Campbell, Christopher;Rath, Lynda;De Ruysscher, Dirk;Lammering, Guido;Hixson, Rosetta;Cesaretti, Jamie;Terk, Mitchell;Ostrer, Harry;Rosenstein, Barry S.
通讯作者：
Rosenstein, Barry S.