A bacterial source for mollusk pyrone polyketides.
A bacterial source for mollusk pyrone polyketides.
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DOI：
10.1016/j.chembiol.2012.10.019
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发表时间：
2013-01-24
影响因子：
--
通讯作者：
Schmidt EW
中科院分区：
文献类型：
--
作者：
Lin Z;Torres JP;Ammon MA;Marett L;Teichert RW;Reilly CA;Kwan JC;Hughen RW;Flores M;Tianero MD;Peraud O;Cox JE;Light AR;Villaraza AJ;Haygood MG;Concepcion GP;Olivera BM;Schmidt EW
在海洋中，有毒的次生代谢物通常会保护原本防御能力较差的软体无脊椎动物，如无壳软体动物免受捕食。这些代谢物的来源在很大程度上是未知的，但其中许多被认为是由共生细菌产生的。相比之下，具有厚壳和有毒毒液的软体动物被认为缺乏这些次级代谢物，因为防御需求减少。在这里，我们表明，严密防御的锥形蜗牛偶尔也含有丰富的次生代谢物，γ-吡喃酮，称为nocapyrones，这些吡喃酮是由共生细菌合成的。这项研究表明，共生细菌可以产生从腹足软体动物中分离出来的代谢物。共生细菌白色诺卡氏菌CR167与潜在分布广泛的放线菌密切相关，我们认为这些放线菌是陆地和海洋中无脊椎动物的偶然共生体。Nocapyrones的天然作用尚不清楚，但它们在神经学分析中的微摩尔水平很低，这表明有外壳的软体动物是次生代谢物多样性的一个被忽视的来源。
In the oceans, toxic secondary metabolites often protect otherwise poorly defended, soft-bodied invertebrates such as shell-less mollusks from predation. The origins of these metabolites are largely unknown, but many of them are thought to be made by symbiotic bacteria. In contrast, mollusks with thick shells and toxic venoms are thought to lack these secondary metabolites due to reduced defensive needs. Here, we show that heavily defended cone snails also occasionally contain abundant secondary metabolites, γ-pyrones known as nocapyrones, and that these pyrones are synthesized by symbiotic bacteria. This study shows that symbiotic bacteria can produce metabolites isolated from gastropod mollusks. The symbiotic bacteria, Nocardiopsis alba CR167, are closely related to potentially widespread actinomycetes that we propose to be casual symbionts of invertebrates on land and in the sea. The natural roles of nocapyrones are not known, but they are active in neurological assays at low micromolar levels, revealing that mollusks with external shells are an overlooked source of secondary metabolite diversity.
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影响因子：
3.2
作者：
Cutignano, Adele;Cimino, Guido;Fontanaa, Angelo
通讯作者：
Fontanaa, Angelo
DOI：
10.1007/978-3-540-30880-5_14
发表时间：
2006-01-01
期刊：
MOLLUSCS: FROM CHEM-ECOLOGICAL STUDY TO BIOTECHNOLOGICAL APPLICATION
影响因子：
--
作者：
Fontana, A.
通讯作者：
Fontana, A.
影响因子：
3.6
作者：
Kubanek, J;Graziani, EI;Andersen, RJ
通讯作者：
Andersen, RJ
DOI：
10.3844/ajidsp.2005.1.4
发表时间：
2005-01-01
期刊：
AMERICAN JOURNAL OF INFECTIOUS DISEASES
影响因子：
--
作者：
Lejbkowicz, Flavio;Kudinsky, Raya;Predescu, Svetlana
通讯作者：
Predescu, Svetlana
影响因子：
1.2
作者：
Marin, A;Alvarez, LA;Spinella, A
通讯作者：
Spinella, A