Optical nerve detection by diffuse reflectance spectroscopy for feedback controlled oral and maxillofacial laser surgery.
Optical nerve detection by diffuse reflectance spectroscopy for feedback controlled oral and maxillofacial laser surgery.
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DOI：
10.1186/1479-5876-9-20
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发表时间：
2011-02-10
影响因子：
7.4
通讯作者：
Schmidt M
中科院分区：
文献类型：
--
作者：
Stelzle F;Zam A;Adler W;Tangermann-Gerk K;Douplik A;Nkenke E;Schmidt M
激光手术缺乏触觉反馈，这伴随着医源性神经损伤的风险。本研究的目的是探讨漫反射光谱对组织分化的影响，作为反馈控制系统的基础，以增强口腔颌面激光手术中神经的保存。在350 ~ 650 nm波长范围内获得了离体家猪面部中部神经组织、唾液腺和骨骼的漫反射光谱（8640光谱）。采用主成分分析（PC）和线性判别分析（LDA）进行组织分化。采用受试者工作特征（ROC）分析和曲线下面积（AUC）计算特异性和敏感性。用LDA的漫反射光谱进行组织分化，发现5个PCs是足够的。神经组织不同于骨，也不同于唾液腺，AUC结果大于88%，灵敏度大于83%，特异性大于78%。漫反射光谱是一种适合于骨和唾液腺附近神经识别的技术。研究结果为口腔颌面激光手术预防医源性神经损伤反馈系统的建立奠定了基础。
Laser surgery lacks haptic feedback, which is accompanied by the risk of iatrogenic nerve damage. It was the aim of this study to investigate diffuse reflectance spectroscopy for tissue differentiation as the base of a feedback control system to enhance nerve preservation in oral and maxillofacial laser surgery. Diffuse reflectance spectra of nerve tissue, salivary gland and bone (8640 spectra) of the mid-facial region of ex vivo domestic pigs were acquired in the wavelength range of 350-650 nm. Tissue differentiation was performed using principal component (PC) analysis followed by linear discriminant analysis (LDA). Specificity and sensitivity were calculated using receiver operating characteristic (ROC) analysis and the area under curve (AUC). Five PCs were found to be adequate for tissue differentiation with diffuse reflectance spectra using LDA. Nerve tissue could be differed from bone as well as from salivary gland with AUC results of greater than 88%, sensitivity of greater than 83% and specificity in excess of 78%. Diffuse reflectance spectroscopy is an adequate technique for nerve identification in the vicinity of bone and salivary gland. The results set the basis for a feedback system to prevent iatrogenic nerve damage when performing oral and maxillofacial laser surgery.
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影响因子：
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作者：
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DOI：
10.1016/s1386-1425(97)00106-6
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