Pollens derived magnetic porous particles for adsorption of low-density lipoprotein from plasma.
Pollens derived magnetic porous particles for adsorption of low-density lipoprotein from plasma.
复制标题
用于从血浆中吸附低密度脂蛋白的花粉衍生磁性多孔颗粒
DOI：
10.1016/j.bioactmat.2020.11.015
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发表时间：
2021-06
影响因子：
18.9
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Wang Y;Sun L;Guo J;Shi K;Shang L;Xiao J;Zhao Y
从血浆中吸附低密度脂蛋白对于治疗血脂异常至关重要。非常需要用于有效和选择性吸附低密度脂蛋白的适当吸附剂材料。在这项工作中，我们开发了花粉衍生的磁性多孔颗粒作为吸附剂用于此目的。对天然花粉粒进行改性以获得高表面孔隙率、大内腔、磁响应性和特定润湿性。所得颗粒在从水中吸附一系列油和有机溶剂方面表现出令人满意的性能。此外，该颗粒可直接用于血浆中低密度脂蛋白的吸附，具有很高的选择性，在2h内吸附率高达34.9%。此外，通过模拟血液灌流实验证明了其显著的生物相容性。这些特征，连同其丰富的来源和容易的制造，使得花粉衍生的磁性多孔颗粒成为低密度脂蛋白单采术和水处理应用的优异候选者。向日葵花粉煅烧生物质多孔吸附剂。多孔花粉粒中空，大孔丰富。两亲性微粒在血浆低密度脂蛋白吸附中的应用。颗粒呈现疏水性，用于去除油和有机溶剂。这些材料表现出高的吸附容量和优异的可重复使用性。
Adsorption of low-density lipoprotein from plasma is vital for the treatment of dyslipidemia. Appropriate adsorbent material for efficient and selective adsorption of low-density lipoprotein is highly desired. In this work, we developed pollens-derived magnetic porous particles as adsorbents for this purpose. The natural pollen grains were modified to obtain high surface porosity, a large inner cavity, magnet responsiveness, and specific wettability. The resultant particles exhibited satisfying performance in the adsorption of a series of oils and organic solvents out of water. Besides, the particles were directly utilized to the adsorption of low-density lipoprotein in plasma, which showed high selectivity, and achieved an outstanding adsorption capacity as high as 34.9% within 2 h. Moreover, their salient biocompatibility was demonstrated through simulative hemoperfusion experiments. These features, together with its abundant source and facile fabrication, makes the pollens-derived magnetic porous particles excellent candidate for low-density lipoprotein -apheresis and water treatment applications. Biomass porous adsorbents calcined from sunflower pollen grains. Lacunaris pollen grains with a hollow structure and abundant macropores. The amphiphilic particles applied in low-density lipoprotein adsorption in plasma. Particles rendered hydrophobic used for removing oil and organic solvents. These materials exhibited high adsorption capacity and excellent reusability.
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影响因子：
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