Effects of isotretinoin on the behavior of neural crest cells in vitro.
Effects of isotretinoin on the behavior of neural crest cells in vitro.
复制标题
异维A酸对体外神经嵴细胞行为的影响。
DOI：
10.1016/0012-1606(87)90449-0
复制
发表时间：
1987
影响因子：
2.7
通讯作者：
M. Bronner‐Fraser
中科院分区：
文献类型：
--
作者：
L. Smith;I. Lott;M. Bronner‐Fraser
Isotretinoin (13-cis-retinoic acid), an anti-acne medication, has been found to cause severe birth defects which affect the craniofacial elements, ear, heart, thymus, and central nervous system. Many of these structures receive contributions from the cranial neural crest. Here, we examine the possibility that these teratogenic effects are due to disturbances in neural crest development. Cranial and trunk neural crest explant cultures were exposed to different concentrations of isotretinoin and the cell morphology was monitored at daily intervals. Treated neural crest cells often became rounded or spindle shaped, separated from their neighbors, and frequently detached from the substrate or clumped together. In contrast, neural tube cells and cardiac fibroblasts were relatively unaffected by the drug. These results suggest that isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion.
影响因子：
56.9
作者：
BOCKMAN, DE;KIRBY, ML
通讯作者：
KIRBY, ML
异维A酸胚胎病和颅神经嵴：体内和体外研究。
DOI：
--
发表时间：
1986
期刊：
Journal of craniofacial genetics and developmental biology
影响因子：
--
作者：
Webster,WS;Johnston,MC;Lammer,EJ;Sulik,KK
通讯作者：
Sulik,KK