SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis.
SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis.
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DOI：
10.1186/s13578-022-00907-2
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发表时间：
2022-10-09
影响因子：
7.5
通讯作者：
Wang, Chunmei
中科院分区：
文献类型：
--
作者：
Yu, Meng;Bean, Jonathan C.;Liu, Hailan;He, Yang;Yang, Yongjie;Cai, Xing;Yu, Kaifan;Pei, Zhou;Liu, Hesong;Tu, Longlong;Conde, Kristine M.;Wang, Mengjie;Li, Yongxiang;Yin, Na;Zhang, Nan;Han, Junying;Scarcelli, Nikolas A.;Xu, Pingwen;He, Yanlin;Xu, Yong;Wang, Chunmei
Pro-opiomelanocortin (POMC) neurons play a sexually dimorphic role in body weight and glucose balance. However, the mechanisms for the sex differences in POMC neuron functions are not fully understood. We detected small conductance calcium-activated potassium (SK) current in POMC neurons. Secondary analysis of published single-cell RNA-Seq data showed that POMC neurons abundantly express SK3, one SK channel subunit. To test whether SK3 in POMC neurons regulates POMC neuron functions on energy and glucose homeostasis, we used a Cre-loxP strategy to delete SK3 specifically from mature POMC neurons. POMC-specific deletion of SK3 did not affect body weight in either male or female mice. Interestingly, male mutant mice showed not only decreased food intake but also decreased physical activity, resulting in unchanged body weight. Further, POMC-specific SK3 deficiency impaired glucose balance specifically in female mice but not in male mice. Finally, no sex differences were detected in the expression of SK3 and SK current in total POMC neurons. However, we found higher SK current but lower SK3 positive neuron population in male POMC neurons co-expressing estrogen receptor α (ERα) compared to that in females. These results revealed a sexually dimorphic role of SK3 in POMC neurons in both energy and glucose homeostasis independent of body weight control, which was associated with the sex difference of SK current in a subpopulation of POMC + ERα + neurons.
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影响因子：
7.7
作者：
Henry FE;Sugino K;Tozer A;Branco T;Sternson SM
通讯作者：
Sternson SM
影响因子：
8.8
作者：
He Y;Shu G;Yang Y;Xu P;Xia Y;Wang C;Saito K;Hinton A Jr;Yan X;Liu C;Wu Q;Tong Q;Xu Y
通讯作者：
Xu Y
影响因子：
4.8
作者：
Appleyard, SM;Hayward, M;Low, MJ
通讯作者：
Low, MJ
DOI：
10.1111/j.1749-6632.1999.tb11298.x
发表时间：
1999-01-01
期刊：
MOLECULAR AND FUNCTIONAL DIVERSITY OF ION CHANNELS AND RECEPTORS
影响因子：
--
作者：
Bond, CT;Maylie, J;Adelman, JP
通讯作者：
Adelman, JP
影响因子：
29
作者：
Hill JW;Elias CF;Fukuda M;Williams KW;Berglund ED;Holland WL;Cho YR;Chuang JC;Xu Y;Choi M;Lauzon D;Lee CE;Coppari R;Richardson JA;Zigman JM;Chua S;Scherer PE;Lowell BB;Brüning JC;Elmquist JK
通讯作者：
Elmquist JK