Human viruses and cancer.
Human viruses and cancer.
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DOI：
10.3390/v6104047
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发表时间：
2014-10-23
期刊：
影响因子：
--
通讯作者：
Fuentes-Pananá EM
中科院分区：
文献类型：
--
作者：
Morales-Sánchez A;Fuentes-Pananá EM
上个世纪中叶，安东尼·爱泼斯坦（Anthony Epstein）、伯特·阿冲（Bert Achong）和伊冯娜·巴尔（Yvonne Barr）在患有伯基特淋巴瘤的非洲儿科患者身上发现了第一种人类肿瘤病毒。迄今为止，七种病毒-EBV，KSHV，高危HPV，MCPV，HBV，HCV和HTLV 1-一直与不同类型的人类癌症有关，据估计，感染占全球所有癌症病例的20%。病毒致癌机制通常包括：基因组不稳定性的产生、细胞增殖速率的增加、对凋亡的抗性、DNA修复机制的改变和细胞极性的改变，这些通常与抗病毒免疫应答的逃避机制共存。病毒因子也间接促进癌症的发展，主要通过免疫抑制或慢性炎症，但也通过慢性抗原刺激。也有证据表明，病毒可以调节已建立的肿瘤的恶性性质。在本工作中，将描述病毒和癌症的因果关系标准，以及在人类肿瘤中符合这些标准的病毒因子，它们的流行病学和生物学特征，它们诱导细胞转化及其相关癌症的分子机制。
The first human tumor virus was discovered in the middle of the last century by Anthony Epstein, Bert Achong and Yvonne Barr in African pediatric patients with Burkitt’s lymphoma. To date, seven viruses -EBV, KSHV, high-risk HPV, MCPV, HBV, HCV and HTLV1- have been consistently linked to different types of human cancer, and infections are estimated to account for up to 20% of all cancer cases worldwide. Viral oncogenic mechanisms generally include: generation of genomic instability, increase in the rate of cell proliferation, resistance to apoptosis, alterations in DNA repair mechanisms and cell polarity changes, which often coexist with evasion mechanisms of the antiviral immune response. Viral agents also indirectly contribute to the development of cancer mainly through immunosuppression or chronic inflammation, but also through chronic antigenic stimulation. There is also evidence that viruses can modulate the malignant properties of an established tumor. In the present work, causation criteria for viruses and cancer will be described, as well as the viral agents that comply with these criteria in human tumors, their epidemiological and biological characteristics, the molecular mechanisms by which they induce cellular transformation and their associated cancers.
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影响因子：
30.8
作者：
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通讯作者：
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影响因子：
3.7
作者：
Cárdenas-Mondragón MG;Carreón-Talavera R;Camorlinga-Ponce M;Gomez-Delgado A;Torres J;Fuentes-Pananá EM
通讯作者：
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20.3
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
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通讯作者：
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