Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva.
Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva.
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人类唾液腺的功能特化和人类唾液固有蛋白质的起源。
DOI：
10.1016/j.celrep.2020.108402
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发表时间：
2020-11-17
期刊：
影响因子：
8.8
通讯作者：
Gokcumen O
中科院分区：
文献类型：
--
作者：
Saitou M;Gaylord EA;Xu E;May AJ;Neznanova L;Nathan S;Grawe A;Chang J;Ryan W;Ruhl S;Knox SM;Gokcumen O
唾液蛋白对于维持口腔和近端消化道的健康至关重要，它们可以作为监测人类健康和疾病的潜在诊断标记物。然而，它们确切的器官起源仍不清楚。通过对成人和胎儿主要唾液腺进行转录组分析，并与唾液蛋白质组、血浆蛋白质组和 28 多个器官的转录组进行整合，我们将人类唾液蛋白与其来源联系起来，识别唾液腺特异性基因，并揭示胎儿和成人特异性基因库。我们的结果还提供了对腺体成熟过程中基因保留程度的见解，并表明成人腺体类型的功能多样性是由数百种转录调节因子的特定剂量组合驱动的，而不是由一些腺体特异性因素驱动的。最后，我们证明了人类腺泡细胞谱系的异质性。我们的结果为未来研究腺体生物学和病理学以及唾液作为诊断液的用途铺平了道路。齐藤等人。对人类胎儿和成人唾液腺转录组变异进行了详细分析。他们的分析揭示了特定的发育和调节过程以及细胞系异质性，这些过程形成了腺体特异性功能变异。
Salivary proteins are essential for maintaining health in the oral cavity and proximal digestive tract, and they serve as potential diagnostic markers for monitoring human health and disease. However, their precise organ origins remain unclear. Through transcriptomic analysis of major adult and fetal salivary glands and integration with the saliva proteome, the blood plasma proteome, and transcriptomes of 28+ organs, we link human saliva proteins to their source, identify salivary-gland-specific genes, and uncover fetal- and adult-specific gene repertoires. Our results also provide insights into the degree of gene retention during gland maturation and suggest that functional diversity among adult gland types is driven by specific dosage combinations of hundreds of transcriptional regulators rather than by a few gland-specific factors. Finally, we demonstrate the heterogeneity of the human acinar cell lineage. Our results pave the way for future investigations into glandular biology and pathology, as well as saliva’s use as a diagnostic fluid. Saitou et al. present a detailed analysis of transcriptome variation among human fetal and adult salivary glands. Their analysis reveals specific developmental and regulatory processes, as well as cell-line heterogeneity, that shape the gland-specific functional variation.
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影响因子：
3.7
作者：
Gerber PA;Hevezi P;Buhren BA;Martinez C;Schrumpf H;Gasis M;Grether-Beck S;Krutmann J;Homey B;Zlotnik A
通讯作者：
Zlotnik A
影响因子：
2.4
作者：
Amano O;Mizobe K;Bando Y;Sakiyama K
通讯作者：
Sakiyama K
预防宿主防御和疾病的唾液粘蛋白。
影响因子：
4.5
作者：
Frenkel ES;Ribbeck K
通讯作者：
Ribbeck K
影响因子：
11.1
作者：
Emmerson E;May AJ;Berthoin L;Cruz-Pacheco N;Nathan S;Mattingly AJ;Chang JL;Ryan WR;Tward AD;Knox SM
通讯作者：
Knox SM
影响因子：
46.9
作者：
Bray, Nicolas L.;Pimentel, Harold;Pachter, Lior
通讯作者：
Pachter, Lior