Expression of chemokine receptors on circulating tumor cells in patients with solid tumors.
Expression of chemokine receptors on circulating tumor cells in patients with solid tumors.
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DOI：
10.1186/1479-5876-10-52
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发表时间：
2012-03-20
影响因子：
7.4
通讯作者：
Keilholz U
中科院分区：
文献类型：
--
作者：
Fusi A;Liu Z;Kümmerlen V;Nonnemacher A;Jeske J;Keilholz U
本研究旨在研究循环肿瘤细胞(CTC)上趋化因子受体(CR)的表达，由于CR是潜在的药物靶点，因此可能对器官特异性转移和肿瘤治疗具有重要意义。用流式细胞仪检测转移癌(MC)和黑色素瘤(MM)患者外周血中CTC的含量，并检测CXCR4、CCR6、CCR7和CCR9的表达。68例患者中49例(72%)检出CTC[28例MC；21例MM]，中位数为3个CTC(范围：1-94个)/10毫升血。CXCR4在CTC和CCR6的表达分别为82%(40/49)和29例(59%；中位数1，范围1~14)。MM患者CTC表达CCR7者6例(29%)，表达CCR9者12例(57%)。未观察到CR的表面表达与器官特异性转移模式呈正相关。实体瘤患者CTC上有CR的表达。结合我们的研究结果，CR可能参与肿瘤细胞的增殖和迁移的观察表明，CTC可能是潜在的CR拮抗剂治疗靶点。
The study was performed to investigate the expression of chemokine receptors (CR) on circulating tumor cells (CTC), which may be of importance for organ-specific metastases and cancer treatment since CR are potential drug-targets. Blood samples from patients with metastatic carcinoma (MC) or melanoma (MM) were enriched for CTC and expression of CR (CXCR4, CCR6, CCR7 and CCR9) was evaluated by flow cytometry. CTC were detected in 49 of 68 patients (72%) [28 MC; 21 MM] with a median number of 3 CTC (range: 1-94)/10 mL of blood. CXCR4 was expressed on CTC in 82% (40/49) of patients [median number 1 CTC/10 mL blood; range 1-14] and CCR6 in 29 patients (59%; median 1, range: 1-14). In MM patients, CCR7 was expressed on CTC in 6 (29%) samples and CCR9 in 12 (57%). A positive correlation between surface expression of CR and organ-specific metastatic pattern was not observed. CR were expressed on CTC of patients with solid tumors. Along with our findings, the observation that CR could be involved in CTC proliferation and migration of tumor cells appoints CTC as potential CR-antagonist therapeutic target.
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影响因子：
45.3
作者：
Ghadjar, P;Coupland, SE;Keilholz, U
通讯作者：
Keilholz, U
影响因子：
50.5
作者：
Cabioglu, N.;Sahin, A. A.;Cristofanilli, M.
通讯作者：
Cristofanilli, M.
影响因子：
11.2
作者：
Marchesi, F;Monti, P;Allavena, P
通讯作者：
Allavena, P
影响因子：
2.2
作者：
Huang, Eugene H.;Singh, Balraj;Lucci, Anthony
通讯作者：
Lucci, Anthony
影响因子：
6.5
作者：
Letsch, A;Keilholz, U;Scheibenbogen, C
通讯作者：
Scheibenbogen, C