Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates.
Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates.
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DOI：
10.1038/s41467-022-29440-z
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发表时间：
2022-04-01
影响因子：
16.6
通讯作者：
Fischer T
中科院分区：
文献类型：
--
作者：
Rutkai I;Mayer MG;Hellmers LM;Ning B;Huang Z;Monjure CJ;Coyne C;Silvestri R;Golden N;Hensley K;Chandler K;Lehmicke G;Bix GJ;Maness NJ;Russell-Lodrigue K;Hu TY;Roy CJ;Blair RV;Bohm R;Doyle-Meyers LA;Rappaport J;Fischer T
Neurological manifestations are a significant complication of coronavirus disease (COVID-19), but underlying mechanisms aren’t well understood. The development of animal models that recapitulate the neuropathological findings of autopsied brain tissue from patients who died from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are critical for elucidating the neuropathogenesis of infection and disease. Here, we show neuroinflammation, microhemorrhages, brain hypoxia, and neuropathology that is consistent with hypoxic-ischemic injury in SARS-CoV-2 infected non-human primates (NHPs), including evidence of neuron degeneration and apoptosis. Importantly, this is seen among infected animals that do not develop severe respiratory disease, which may provide insight into neurological symptoms associated with “long COVID”. Sparse virus is detected in brain endothelial cells but does not associate with the severity of central nervous system (CNS) injury. We anticipate our findings will advance our current understanding of the neuropathogenesis of SARS-CoV-2 infection and demonstrate SARS-CoV-2 infected NHPs are a highly relevant animal model for investigating COVID-19 neuropathogenesis among human subjects. COVID-19 can result in neurological manifestations and animal models could provide insights into the mechanisms. Here, the authors describe neuroinflammation, microhemorrhages and brain hypoxia in SARS-CoV-2 infected non-human primates, including in animals that don’t develop severe respiratory disease.
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DOI：
10.1016/s1474-4422(20)30308-2
发表时间：
2020-11
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Matschke J;Lütgehetmann M;Hagel C;Sperhake JP;Schröder AS;Edler C;Mushumba H;Fitzek A;Allweiss L;Dandri M;Dottermusch M;Heinemann A;Pfefferle S;Schwabenland M;Sumner Magruder D;Bonn S;Prinz M;Gerloff C;Püschel K;Krasemann S;Aepfelbacher M;Glatzel M
通讯作者：
Glatzel M
影响因子：
2.4
作者：
Fitsiori, Aikaterini;Pugin, Deborah;Vargas, Maria Isabel
通讯作者：
Vargas, Maria Isabel
影响因子：
4.4
作者：
Frontera JA;Yang D;Lewis A;Patel P;Medicherla C;Arena V;Fang T;Andino A;Snyder T;Madhavan M;Gratch D;Fuchs B;Dessy A;Canizares M;Jauregui R;Thomas B;Bauman K;Olivera A;Bhagat D;Sonson M;Park G;Stainman R;Sunwoo B;Talmasov D;Tamimi M;Zhu Y;Rosenthal J;Dygert L;Ristic M;Ishii H;Valdes E;Omari M;Gurin L;Huang J;Czeisler BM;Kahn DE;Zhou T;Lin J;Lord AS;Melmed K;Meropol S;Troxel AB;Petkova E;Wisniewski T;Balcer L;Morrison C;Yaghi S;Galetta S
通讯作者：
Galetta S
影响因子：
7.3
作者：
Hamming, I;Timens, W;van Goor, H
通讯作者：
van Goor, H
DOI：
10.1016/j.ajpath.2020.10.016
发表时间：
2021-03
期刊：
The American journal of pathology
影响因子：
--
作者：
Blair RV;Vaccari M;Doyle-Meyers LA;Roy CJ;Russell-Lodrigue K;Fahlberg M;Monjure CJ;Beddingfield B;Plante KS;Plante JA;Weaver SC;Qin X;Midkiff CC;Lehmicke G;Golden N;Threeton B;Penney T;Allers C;Barnes MB;Pattison M;Datta PK;Maness NJ;Birnbaum A;Fischer T;Bohm RP;Rappaport J
通讯作者：
Rappaport J