Acute Respiratory Distress in Aged, SARS-CoV-2-Infected African Green Monkeys but Not Rhesus Macaques.
Acute Respiratory Distress in Aged, SARS-CoV-2-Infected African Green Monkeys but Not Rhesus Macaques.
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感染SARS-CoV-2的老年非洲绿猴的急性呼吸窘迫，但不是恒河猴。
DOI：
10.1016/j.ajpath.2020.10.016
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Rappaport J
中科院分区：
文献类型：
--
作者：
Blair RV;Vaccari M;Doyle-Meyers LA;Roy CJ;Russell-Lodrigue K;Fahlberg M;Monjure CJ;Beddingfield B;Plante KS;Plante JA;Weaver SC;Qin X;Midkiff CC;Lehmicke G;Golden N;Threeton B;Penney T;Allers C;Barnes MB;Pattison M;Datta PK;Maness NJ;Birnbaum A;Fischer T;Bohm RP;Rappaport J
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)可引起多种疾病，从无症状感染到危及生命的疾病，特别是在老年人口和患有共病的人中。在患有严重冠状病毒2019(新冠肺炎)疾病的患者中，急性呼吸窘迫综合征是一种常见的且往往是致命的表现。需要建立严重疾病的SARS-CoV-2感染动物模型来研究新冠肺炎诱导的急性呼吸窘迫综合征的发病机制和评估治疗策略。我们报告了两例感染SARS-CoV-2的老年非洲绿猴(AGM)急性呼吸窘迫综合征(ARDS)的病例，其病理损害和疾病类似于人类严重的新冠肺炎。我们还报告了两个存活的老年AM和四个感染SARS-CoV-2的恒河猴(RMS)的相对轻微的新冠肺炎表型，其特征是轻微的临床、放射学和组织病理学变化。在四个感染的老年AM中有三个观察到循环细胞因子的显著增加，但在感染的RMS中没有。与基线相比，所有AGM的血浆IL-6水平都有所上升，IL-6是感染SARS-CoV-2的人类的一个预测标记和推定的治疗目标。总之，我们的结果表明，RMS和AGMS都能够模拟SARS-CoV-2感染，并表明老年AGM可能有助于模拟包括ARDS在内的严重疾病表现。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a wide range of disease severity, ranging from asymptomatic infection to a life-threating illness, particularly in the elderly population and individuals with comorbid conditions. Among individuals with serious coronavirus 2019 (COVID-19) disease, acute respiratory distress syndrome (ARDS) is a common and often fatal presentation. Animal models of SARS-CoV-2 infection that manifest severe disease are needed to investigate the pathogenesis of COVID-19–induced ARDS and evaluate therapeutic strategies. We report two cases of ARDS in two aged African green monkeys (AGMs) infected with SARS-CoV-2 that had pathological lesions and disease similar to severe COVID-19 in humans. We also report a comparatively mild COVID-19 phenotype characterized by minor clinical, radiographic, and histopathologic changes in the two surviving, aged AGMs and four rhesus macaques (RMs) infected with SARS-CoV-2. Notable increases in circulating cytokines were observed in three of four infected, aged AGMs but not in infected RMs. All the AGMs had increased levels of plasma IL-6 compared with baseline, a predictive marker and presumptive therapeutic target in humans infected with SARS-CoV-2. Together, our results indicate that both RMs and AGMs are capable of modeling SARS-CoV-2 infection and suggest that aged AGMs may be useful for modeling severe disease manifestations, including ARDS.
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影响因子：
64.8
作者：
van Doremalen N;Lambe T;Spencer A;Belij-Rammerstorfer S;Purushotham JN;Port JR;Avanzato VA;Bushmaker T;Flaxman A;Ulaszewska M;Feldmann F;Allen ER;Sharpe H;Schulz J;Holbrook M;Okumura A;Meade-White K;Pérez-Pérez L;Edwards NJ;Wright D;Bissett C;Gilbride C;Williamson BN;Rosenke R;Long D;Ishwarbhai A;Kailath R;Rose L;Morris S;Powers C;Lovaglio J;Hanley PW;Scott D;Saturday G;de Wit E;Gilbert SC;Munster VJ
通讯作者：
Munster VJ
影响因子：
--
作者：
Weiss SR;Leibowitz JL
通讯作者：
Leibowitz JL
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
DOI：
10.1164/ajrccm.163.7.2009111
发表时间：
2001-06-01
影响因子：
24.7
作者：
O'Grady, NP;Preas, HL;Suffredini, AF
通讯作者：
Suffredini, AF
影响因子：
9
作者：
Channappanavar R;Perlman S
通讯作者：
Perlman S