The type II secretion system: biogenesis, molecular architecture and mechanism.
The type II secretion system: biogenesis, molecular architecture and mechanism.
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DOI:
10.1038/nrmicro2762
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发表时间:
2012-04-02
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--
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Many Gram-negative bacteria use the sophisticated type II secretion system (T2SS) to translocate a wide range of proteins from the periplasm across the outer membrane. The inner membrane platform of the T2SS is the nexus of the system and interacts with the periplasmic filamentous pseudopilus, the dodecameric outer membrane complex and a cytoplasmic secretion ATPase to orchestrate the secretion process. Here recent structural and biochemical information is reviewed to describe our current insights of the biogenesis, architecture and mechanism of the T2SS.
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Bayan, N
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3.2
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