The type II secretion system: biogenesis, molecular architecture and mechanism.

The type II secretion system: biogenesis, molecular architecture and mechanism.
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DOI:
10.1038/nrmicro2762
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发表时间:
2012-04-02
期刊:
Nature reviews. Microbiology
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许多革兰氏阴性菌利用复杂的II型分泌系统(T2SS)将大量蛋白质从质周转运到外膜。T2SS的内膜平台是该系统的纽带,并与质周丝状假毛囊、十二聚体外膜复合物和细胞质分泌atp酶相互作用,以协调分泌过程。本文回顾了最近的结构和生化信息,以描述我们目前对T2SS的生物发生、结构和机制的见解。
Many Gram-negative bacteria use the sophisticated type II secretion system (T2SS) to translocate a wide range of proteins from the periplasm across the outer membrane. The inner membrane platform of the T2SS is the nexus of the system and interacts with the periplasmic filamentous pseudopilus, the dodecameric outer membrane complex and a cytoplasmic secretion ATPase to orchestrate the secretion process. Here recent structural and biochemical information is reviewed to describe our current insights of the biogenesis, architecture and mechanism of the T2SS.
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