Comparison of diabetic retinopathy severity grading on ETDRS 7-field versus ultrawide-field assessment.

Comparison of diabetic retinopathy severity grading on ETDRS 7-field versus ultrawide-field assessment.
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DOI:
10.1038/s41433-023-02445-8
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发表时间:
2023-10
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Eye (London, England)
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比较仅考虑ETDRS 7场区域与整个超宽场(UWF)图像时确定的糖尿病视网膜病变(DR)严重程度水平。在这项回顾性横断面研究中,仅考虑ETDRS 7视野内的区域以及整个UWF图像,使用两种不同的方案在Eyenuk图像查看、分级和注释平台上对UWF伪彩色图像进行DR严重程度分级:1)简单的糖尿病视网膜病变国际分类(ICDR)量表和2)更复杂的DRCR.net Protocol AA分级量表。共有157例患者的250只眼纳入本分析。当使用ICDR分类系统时,6只眼睛(2.4%)表现出ETDRS 7视野区域和整个UWF图像之间的严重程度差异。差异是由于ETDRS 7视野中未识别的外周视野中存在病变[视网膜内出血(n = 2),新生血管性疾病(n = 4)]。当使用ETDRS DRSS方案AA分级量表时,14只眼(5.6%)的ETDRS 7视野区域和整个UWF图像之间的严重程度存在差异。差异是由于周边视野中存在较高水平的疾病[视网膜内出血(n = 4)、新生血管形成(n = 4)、视网膜前出血(n = 2)、散射激光瘢痕(n = 4)]。尽管考虑到ETDRS 7视野以外的区域改变了该队列中<5%病例的DR严重程度评估,但在这些外周区域中发现了显著和潜在的视力威胁性病变,包括新生血管形成和视网膜前出血。这突出了在评估糖尿病视网膜病变患者时评估整个UWF区域的重要性。
To compare the diabetic retinopathy (DR) severity level determined when considering only the ETDRS 7-field region versus the entire ultrawidefield (UWF) image. In this retrospective, cross-sectional study, UWF pseudocolor images were graded on the Eyenuk image viewing, grading, and annotation platform for the severity of DR considering only the regions within the ETDRS 7-fields as well as the entire UWF image using two different protocols: 1) the simple International Classification of Diabetic Retinopathy (ICDR) scale and 2) the more complex DRCR.net Protocol AA grading scale. A total of 250 eyes from 157 patients were included in this analysis. Six eyes (2.4%) demonstrated a discrepancy in severity level between the ETDRS 7-field region and the entire UWF image when using the ICDR classification system. The discrepancies were due to the presence of lesions [intraretinal haemorrhage (n = 2), neovascular disease (n = 4)] in the peripheral fields which were not identified in the ETDRS 7-fields. Fourteen eyes (5.6%) had a discrepancy in severity level between the ETDRS 7-field region and the entire UWF image when using the ETDRS DRSS Protocol AA grading scale. The discrepancies were due to the presence of a higher level of disease [intraretinal haemorrhage (n = 4), neovascularization (n = 4), preretinal haemorrhage (n = 2), scatter laser scars (n = 4)] in the peripheral fields. Although considering regions outside of the ETDRS 7-fields altered the DR severity level assessment in <5% of cases in this cohort, significant and potentially vision-threatening lesions including neovascularization and preretinal haemorrhage were identified in these peripheral regions. This highlights the importance of evaluating the entire UWF region when assessing patients with diabetic retinopathy.
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