Small-molecule based musculoskeletal regenerative engineering.

Small-molecule based musculoskeletal regenerative engineering.
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DOI:
10.1016/j.tibtech.2013.12.002
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发表时间:
2014-02
影响因子:
17.3
通讯作者:
Laurencin, Cato T.
Laurencin, Cato T.
中科院分区:
工程技术1区
文献类型:
--
作者:
Lo, Kevin W. -H.;Jiang, Tao;Gagnon, Keith A.;Nelson, Clarke;Laurencin, Cato T.

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在再生工程领域工作的临床医生和科学家正在积极研究各种促进肌肉骨骼组织再生的方法。小分子介导的组织再生是一种很有前景的肌肉骨骼组织再生策略,近年来发现了大量的小分子化合物作为潜在的生物活性分子用于肌肉骨骼组织的修复和再生。在这篇综述中,我们总结了最近的文献,包括过去四年在促进各种肌肉骨骼组织的修复和再生方面的生物活性小分子,包括骨、肌肉、软骨、肌腱和神经。
Clinicians and scientists working in the field of regenerative engineering are actively investigating a wide range of methods to promote musculoskeletal tissue regeneration. Small molecule-mediated tissue regeneration is emerging as a promising strategy for regenerating various musculoskeletal tissues and a large number of small molecule compounds have been recently discovered as potential bioactive molecules for musculoskeletal tissue repair and regeneration. In this review, we summarize the recent literature encompassing the past four years in the area of small bioactive molecule for promoting repair and regeneration of various musculoskeletal tissues including bone, muscle, cartilage, tendon, and nerve.
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