Current Understanding of Circulating Biomarkers in Pulmonary Hypertension Due to Left Heart Disease.
Current Understanding of Circulating Biomarkers in Pulmonary Hypertension Due to Left Heart Disease.
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DOI：
10.3389/fmed.2020.570016
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发表时间：
2020
影响因子：
3.9
通讯作者：
Lai YC
中科院分区：
文献类型：
--
作者：
Todd N;Lai YC
Pulmonary hypertension due to left heart disease (PH-LHD; Group 2), especially in the setting of heart failure with preserved ejection fraction (HFpEF), is the most frequent cause of PH. Despite its prevalence, no effective therapies for PH-LHD are available at present. This is largely due to the lack of a concise definition for hemodynamic phenotyping, existence of significant gaps in the understanding of the underlying pathology and the impact of associated comorbidities, as well as the absence of specific biomarkers that can aid in the early diagnosis and management of this challenging syndrome. Currently, B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are guideline-recommended biomarkers for the diagnosis and prognosis of heart failure (HF) and PH. Endothelin-1 (ET-1), vascular endothelial growth factor-D (VEGF-D), and microRNA-206 have also been recently identified as new potential circulating biomarkers for patients with PH-LHD. In this review, we aim to present the current state of knowledge of circulating biomarkers that can be used to guide future research toward diagnosis, refine specific patient phenotype, and develop therapeutic approaches for PH-LHD, with a particular focus on PH-HFpEF. Potential circulating biomarkers identified in pre-clinical models of PH-LHD are also summarized here.
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影响因子：
3.8
作者：
Chen H;Guan R;Lei Y;Chen J;Ge Q;Zhang X;Dou R;Chen H;Liu H;Qi X;Zhou X;Chen C
通讯作者：
Chen C
DOI：
10.1016/j.amjcard.2012.05.014
发表时间：
2012-09-15
期刊：
The American journal of cardiology
影响因子：
--
作者：
Anjan VY;Loftus TM;Burke MA;Akhter N;Fonarow GC;Gheorghiade M;Shah SJ
通讯作者：
Shah SJ
影响因子：
5.7
作者：
Berntsson, John;Smith, J. Gustav;Engstrom, Gunnar
通讯作者：
Engstrom, Gunnar
DOI：
10.1073/pnas.95.2.548
发表时间：
1998-01-20
影响因子：
11.1
作者：
Achen, MG;Jeltsch, M;Stacker, SA
通讯作者：
Stacker, SA
影响因子：
6.2
作者：
Gorter, Thomas M.;van Veldhuisen, Dirk J.;Hoendermis, Elke S.
通讯作者：
Hoendermis, Elke S.