Novel inducers of the envelope stress response BaeSR in Salmonella Typhimurium: BaeR is critically required for tungstate waste disposal.
Novel inducers of the envelope stress response BaeSR in Salmonella Typhimurium: BaeR is critically required for tungstate waste disposal.
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鼠伤寒沙门氏菌中包膜应激反应 BaeSR 的新型诱导剂：BaeR 对于钨酸盐废物处理至关重要。
DOI：
10.1371/journal.pone.0023713
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Rowley G
中科院分区：
文献类型：
--
作者：
Appia-Ayme C;Patrick E;Sullivan MJ;Alston MJ;Field SJ;AbuOun M;Anjum MF;Rowley G
RpoE和CpxR调控的包膜应激反应对于沙门氏菌在一系列宿主中引起感染至关重要。到目前为止，BaeSR在鼠伤寒沙门氏菌对应激反应及其对感染的贡献中的作用尚未完全阐明。在这里，我们证明了固定相生长，铁和钨酸钠作为BaeR调控的新型诱导剂，其中BaeR对于沙门氏菌对钨酸钠的抗性至关重要。我们发现耐药结节-细胞分裂（RND）多药转运体、MdtA、AcrD和AcrB之间存在功能重叠，用于处理细胞中的钨酸盐废物。我们还指出肠杆菌铁载体在保护肠道生物免受钨酸盐侵害中的作用，类似于固氮细菌的情况。令人惊讶的是，在Typhimurium中，BaeR是第一个被研究的包膜应激反应途径，而在tyys或tyr小鼠背景下，该途径都不是小鼠伤寒所必需的。因此，拜耳要么是大型哺乳动物（如猪或小牛）的生存所必需的，要么是禽类宿主（如鸡）的生存所必需的，要么是与宿主一起生存，沙门氏菌和相关肠道菌必须在土壤和水中生存。
The RpoE and CpxR regulated envelope stress responses are extremely important for SalmonellaTyphimurium to cause infection in a range of hosts. Until now the role for BaeSR in both the Salmonella Typhimurium response to stress and its contribution to infection have not been fully elucidated. Here we demonstrate stationary phase growth, iron and sodium tungstate as novel inducers of the BaeRregulon, with BaeR critically required for Salmonella resistance to sodium tungstate. We show that functional overlap between the resistance nodulation-cell division (RND) multidrug transporters, MdtA, AcrD and AcrB exists for the waste disposal of tungstate from the cell. We also point to a role for enterobactinsiderophores in the protection of enteric organisms from tungstate, akin to the scenario in nitrogen fixing bacteria. Surprisingly, BaeR is the first envelope stress response pathway investigated in S. Typhimurium that is not required for murine typhoid in either ityS or ityR mouse backgrounds. BaeR is therefore either required for survival in larger mammals such as pigs or calves, an avian host such as chickens, or survival out with the host altogether where Salmonella and related enterics must survive in soil and water.
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影响因子：
3.5
作者：
CHEREPANOV, PP;WACKERNAGEL, W
通讯作者：
WACKERNAGEL, W
影响因子：
3
作者：
Alston MJ;Seers J;Hinton JC;Lucchini S
通讯作者：
Lucchini S
影响因子：
3.2
作者：
Beck, BJ;Connolly, LE;Downs, DM
通讯作者：
Downs, DM
影响因子：
11.4
作者：
Jones, CH;Danese, PN;Hultgren, SJ
通讯作者：
Hultgren, SJ
DOI：
10.1142/s0219720005001442
发表时间：
2005-10-01
影响因子：
1
作者：
Breitling, Rainer;Herzyk, Pawel
通讯作者：
Herzyk, Pawel