Artemisia annua glandular secretory trichomes: the biofactory of antimalarial agent artemisinin
Artemisia annua glandular secretory trichomes: the biofactory of antimalarial agent artemisinin
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青蒿腺体分泌毛：抗疟药青蒿素的生物工厂
DOI：
10.1007/s11434-015-0980-z
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发表时间：
2016-01
期刊：
影响因子：
18.9
通讯作者：
Lei Zhang
中科院分区：
文献类型：
--
作者：
Ling Xiao;Hexin Tan;Lei Zhang
青蒿素是一线抗疟疾药物的关键成分，每年都有很大的需求。产少量青蒿素的原生植物仍然是其主要来源，因此导致青蒿素供应短缺。加大了提高青蒿素产量的力度。然而，常规的代谢工程策略，通过过度表达或下调青蒿素生物合成分支途径的基因，并不是很有效。青蒿腺分泌毛是青蒿素生物合成的场所，是提高青蒿素产量的新靶点。总体而言，青蒿腺分泌毛的数量和形态与青蒿素含量呈正相关。对AaGSTs的更好理解将有助于揭示增加植物来源青蒿素的机会。这篇综述文章将更新毛状体的分类，并提供关于AaGSTs和青蒿素的最新研究成果。为了充分了解AaGSTs，与毛状体形态和密度相关的因素还需要进一步研究，如基因、microRNAs和植物激素。本综述的目的是(1)更新对AaGSTs和青蒿素之间关系的认识，以及(2)通过利用潜在的生物工厂AaGSTs来提出提高青蒿素产量的新途径。
Artemisinin, the key ingredient of first-line antimalarial drugs, has large demand every year. The native plant, which produces small quantities of artemisinin, remains as its main source and thus results in a short supply of artemisinin. Intensified efforts have been carried out to elevate artemisinin production. However, the routine metabolic engineering strategy, via overexpressing or down-regulating genes in artemisinin biosynthesis branch pathways, was not very effective as desired. Glandular secretory trichomes, sites of artemisinin biosynthesis on the surface of Artemisia annua L. (A. annua), are the new target for increasing artemisinin yield. In general, the population and morphology of glandular secretory trichomes in A. annua (AaGSTs) are often positively correlated with artemisinin content. Improved understanding of AaGSTs will shed light on the opportunities for increasing plant-derived artemisinin. This review article will refresh classification of trichomes in A. annua and provide an overview of the recent achievements regarding AaGSTs and artemisinin. To have a full understanding of AaGSTs, factors that are associated with trichome morphology and density will have to be further investigated, such as genes, microRNAs and phytohormones. The purpose of this review was to (1) update the knowledge of the relation between AaGSTs and artemisinin, and (2) propose new avenues to increase artemisinin yield by harnessing the potential biofactories, AaGSTs.
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影响因子：
--
作者：
Zhang F;Fu X;Lv Z;Shen Q;Yan T;Jiang W;Wang G;Sun X;Tang K
通讯作者：
Tang K
影响因子：
1.1
作者：
Teoh, Keat H.;Polichuk, Devin R.;Covello, Patrick S.
通讯作者：
Covello, Patrick S.
影响因子：
2.1
作者：
Brown, GD;Sy, LK
通讯作者：
Sy, LK
DOI：
10.1002/chin.200742266
发表时间：
2007-10
期刊：
ChemInform
影响因子：
--
作者：
P. Covello;K. Teoh;Devin R. Polichuk;D. Reed;Goska Nowak
通讯作者：
P. Covello;K. Teoh;Devin R. Polichuk;D. Reed;Goska Nowak
DOI：
--
发表时间：
2011-04
期刊：
Yao xue xue bao = Acta pharmaceutica Sinica
影响因子：
--
作者：
Xiao-Bo Zhang;Lan-Ping Guo;Lu‐qi Huang
通讯作者：
Xiao-Bo Zhang;Lan-Ping Guo;Lu‐qi Huang