G6PD deficiency in Plasmodium falciparum and Plasmodium vivax malaria-infected Cambodian patients.
G6PD deficiency in Plasmodium falciparum and Plasmodium vivax malaria-infected Cambodian patients.
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DOI：
10.1186/1475-2875-12-171
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发表时间：
2013-05-28
期刊：
影响因子：
3
通讯作者：
Ménard D
中科院分区：
文献类型：
--
作者：
Khim N;Benedet C;Kim S;Kheng S;Siv S;Leang R;Lek S;Muth S;Chea N;Chuor CM;Duong S;Kerleguer A;Tor P;Chim P;Canier L;Witkowski B;Taylor WR;Ménard D
葡萄糖-6-磷酸脱氢酶缺乏症（G6 PDd）率是未知的疟疾感染的柬埔寨患者。这些数据是制定合理的疟疾药物政策、消灭恶性疟原虫和间日疟原虫的关键。从2010年9月至2012年，在柬埔寨全国19个保健中心就诊的疟疾感染患者中进行了一项为期两年的G6 PDd和血红蛋白病调查，分别通过定量酶活性测定和血红蛋白电泳进行评估。共招募了2，408例确诊的疟疾患者，平均年龄26.7岁（范围2-81），主要来自柬埔寨西部（n = 1，732，71.9%）;男性与女性的比例为3.9：1。1，443例（59.9%）患者存在恶性疟原虫，965例（40.1%）患者存在间日疟原虫。平均G6 PD活性为11.6（CI 95%：11.4-11.8）U/g Hb，13.9%的患者（335/2，408）存在G6 PDd，柬埔寨西部（158/1，732，9.1%）与东部（21/414，5.1%）相比，重度G6 PDd（包括WHO I类和II类变异体）更常见（P = 0.01）。在997/2，408（41.4%）例患者中，有血红蛋白病。平均血红蛋白浓度与年龄呈负相关：<5岁为8.1 g/dL，5至14岁为8.7 g/dL，>15岁为10.4 g/dL（P <0.001）。G6 PDd患病率、贫血和血红蛋白病在疟疾感染患者中很常见。在柬埔寨使用伯氨喹之前，应进行伯氨喹安全性研究，并对易于使用的G6 PDd检测方法进行评价。
Glucose-6-phosphate-dehydrogenase deficiency (G6PDd) rates are unknown in malaria-infected Cambodian patients. These data are key to a rational drug policy for malaria elimination of Plasmodium falciparum and Plasmodium vivax. From September 2010–2012, a two-year survey of G6PDd and haemoglobinopathies assessed by quantitative enzyme activity assay and haemoglobin electrophoresis, respectively, was conducted in malaria-infected patients presenting to 19 health centres throughout Cambodia. A total of 2,408 confirmed malaria patients of mean age 26.7 (range 2–81) years were recruited from mostly western Cambodia (n = 1,732, 71.9%); males outnumbered females by 3.9:1. Plasmodium falciparum was present in 1,443 (59.9%) and P. vivax in 965 (40.1%) patients. Mean G6PD activity was 11.6 (CI 95%: 11.4-11.8) U/g Hb, G6PDd was present in 13.9% of all patients (335/2,408) and severe G6PDd (including WHO Class I and II variants) was more common in western (158/1,732, 9.1%) versus eastern (21/414, 5.1%) Cambodia (P = 0.01). Of 997/2,408 (41.4%) had a haemoglobinopathy. Mean haemoglobin concentrations were inversely related to age: 8.1 g/dL < five years, 8.7 g/dL five to 14 years, and 10.4 g/dL >15 years (P <0.001). G6PDd prevalence, anaemia and haemoglobinopathies were common in malaria-infected patients. The deployment of primaquine in Cambodia should be preceded by primaquine safety studies paralleled with evaluations of easy to use tests to detect G6PDd.
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DOI：
10.1056/nejmp1108322
发表时间：
2011-09-22
期刊：
The New England journal of medicine
影响因子：
--
作者：
Dondorp AM;Fairhurst RM;Slutsker L;Macarthur JR;Breman JG;Guerin PJ;Wellems TE;Ringwald P;Newman RD;Plowe CV
通讯作者：
Plowe CV
影响因子：
3.5
作者：
Louicharoen, C;Nuchprayoon, I
通讯作者：
Nuchprayoon, I
DOI：
10.1073/pnas.48.1.9
发表时间：
1962-01-01
影响因子：
11.1
作者：
BEUTLER, E;FAIRBANKS, VF;YEH, M
通讯作者：
YEH, M
影响因子：
3.5
作者：
Matsuoka, H;Nguon, C;Kawamoto, F
通讯作者：
Kawamoto, F
影响因子：
3
作者：
von Seidlein L;Auburn S;Espino F;Shanks D;Cheng Q;McCarthy J;Baird K;Moyes C;Howes R;Ménard D;Bancone G;Winasti-Satyahraha A;Vestergaard LS;Green J;Domingo G;Yeung S;Price R
通讯作者：
Price R