Susceptibility gradient mapping (SGM): a new postprocessing method for positive contrast generation applied to superparamagnetic iron oxide particle (SPIO)-labeled cells.
Susceptibility gradient mapping (SGM): a new postprocessing method for positive contrast generation applied to superparamagnetic iron oxide particle (SPIO)-labeled cells.
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DOI：
10.1002/mrm.21478
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发表时间：
2008-09
影响因子：
3.3
通讯作者：
Schaeffter, Tobias
中科院分区：
文献类型：
--
作者：
Dahnke, Hannes;Liu, Wei;Herzka, Daniel;Frank, Joseph A.;Schaeffter, Tobias
局部磁化率梯度导致进动磁矩失相，从而导致 NMR 信号快速衰减。特别是，用超顺磁性氧化铁颗粒（SPIO）标记的细胞会引起低信号，使得从这种负图像对比度体内检测标记细胞变得困难。在这项工作中，提出了一种新方法来选择性地将这种负面对比变成正面对比。所提出的方法计算磁化率梯度并直接从常规梯度回波图像数据集在参数图中将其可视化。磁化率梯度图在后处理步骤中确定，无需专用脉冲序列或在图像采集之前和期间对序列进行调整。模型实验表明，局部敏感性差异是可以量化的。体内实验表明了该方法追踪SPIO标记细胞的可行性。该方法还具有用于其他应用的潜力，包括造影剂和介入设备以及金属植入物的检测。
Local susceptibility gradients result in a dephasing of the precessing magnetic moments and thus in a fast decay of the NMR signals. In particular, cells labeled with superparamagnetic iron oxide particles (SPIOs) induce hypointensities, making the in vivo detection of labeled cells from such a negative image contrast difficult. In this work, a new method is proposed to selectively turn this negative contrast into a positive contrast. The proposed method calculates the susceptibility gradient and visualizes it in a parametric map directly from a regular gradient-echo image dataset. The susceptibility gradient map is determined in a postprocessing step, requiring no dedicated pulse sequences or adaptation of the sequence before and during image acquisition. Phantom experiments demonstrated that local susceptibility differences can be quantified. In vivo experiments showed the feasibility of the method for tracking of SPIO-labeled cells. The method bears the potential also for usage in other applications, including the detection of contrast agents and interventional devices as well as metal implants.
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影响因子：
3.3
作者：
Bowen, CV;Zhang, XW;Rutt, BK
通讯作者：
Rutt, BK
影响因子：
3.3
作者：
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DOI：
10.1073/pnas.96.26.15256
发表时间：
1999-12-21
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
3.4
作者：
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通讯作者：
UGURBIL, K
影响因子：
3.3
作者：
Bakker, CJ;Hoogeveen, RM;Mali, WP
通讯作者：
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