N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI).
N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI).
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DOI：
10.12659/msm.882112
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Gabryelewicz T
中科院分区：
文献类型：
--
作者：
Walecki J;Barcikowska M;Ćwikła JB;Gabryelewicz T
本研究的目的是使用1H MRS评估MCI患者的局部代谢紊乱，作为临床随访基础上临床转化为痴呆的预测因子。研究组由31名根据马约诊所小组标准诊断为MCI的受试者组成。采用PRESS序列，采用单体素方法进行1H MR扫描。感兴趣体积（VOI）位于海马结构和扣带回后部。患者每年至少有两次临床控制。开始时9例为遗忘型MCI，其余为多领域MCI。在随访期间（中位数3年），8名受试者病情稳定（SD），13名疾病进展（DP），10名发展为阿尔茨海默病（AD）。3组间基础代谢率（1HMRS）显示左额叶mI/H20比值SD组（0.27）与DP组（0.27）差异有显著性（P<0.05）。SD组与DP组比较，NAA/Cr（1.77 vs.1.43）、NAA/H2O（0.55 vs.0.51）在左颞外叶有显著性差异。DP和AD的右侧内侧颞叶内Glx/H2O比值（0.44 vs. 0.34）存在显著差异。1H MRS似乎是一种敏感的方法，可以预测哪些患者易于从MCI进展为AD。结合其他疾病分期的生物标志物，它是临床前AD诊断以及评估痴呆进展的重要方法。
Purpose of study was evaluation of regional metabolic disorders using 1H MRS in patients with MCI, as a predictor of clinical conversion to dementia based on clinical follow-up. The study group consisted of 31 subjects with diagnosis of MCI based on criteria the Mayo Clinic Group. 1H MRS was performed with a single-voxel method using PRESS sequence. The volume of interest (VOI) was located in the hippocampal formation and posterior part of the cingulated gyrus. Patients had annual clinical control at least twice. At the beginning, 9 had amnestic MCI and the others had multidomain MCI. During follow-up (median 3 yrs) 8 subjects had stable disease (SD), 13 had disease progression (DP) and 10 develop Alzheimer disease (AD). Baseline metabolic ratios (1H MRS) between 3 groups indicated significant difference (P<0.05) in left frontal lobe in mI/H20 ratio, between patients with SD (0.27) and DP. In comparing the groups with DP and AD, a significant difference in NAA/Cr (1.77 vs. 1.43) was found. A significant difference within left temporal external lobes was found between SD and DP in NAA/H2O ratio (0.55 vs. 0.51). An additional significant difference within medial temporal lobe was found between DP and AD in Glx/H2O ratio (0.44 vs. 0.34) on the right side. 1H MRS seems to be sensitive method allows prediction of which patients are liable to progress from MCI to AD. Combined with other biomarkers of disease staging, it is an important approach in the preclinical AD diagnosis, as well as the assessment of dementia progression.
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影响因子：
4.2
作者：
Metastasio, Antonio;Rinaldi, Patrizia;Mecocci, Patrizia
通讯作者：
Mecocci, Patrizia
影响因子：
9.9
作者：
Jack, CR;Petersen, RC;Kokmen, E
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Kokmen, E
影响因子：
5.1
作者：
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Celda, B
DOI：
10.1073/pnas.89.5.1671
发表时间：
1992-03-01
影响因子：
11.1
作者：
NITSCH, RM;BLUSZTAJN, JK;WURTMAN, RJ
通讯作者：
WURTMAN, RJ
影响因子：
9.9
作者：
Devanand, D. P.;Pradhaban, G.;de Leon, M. J.
通讯作者：
de Leon, M. J.