Ischemic preconditioning does not acutely improve load-insensitive parameters of contractility in in vivo stunned porcine myocardium.
Ischemic preconditioning does not acutely improve load-insensitive parameters of contractility in in vivo stunned porcine myocardium.
复制标题
缺血预处理并不能显着改善体内顿顿猪心肌的负荷不敏感收缩参数。
DOI：
10.1016/s0022-5223(99)70303-x
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
MentzerJr,RM
中科院分区：
文献类型：
--
作者：
Jahania,MS;Lasley,RD;MentzerJr,RM
目的缺血预处理对局部昏迷心肌的节段缩短无明显影响。本研究的目的是通过负荷不敏感的测量来评估收缩性，包括收缩压长度关系、负荷前可恢复的卒中工作和负荷前可恢复的卒中工作面积，来确定缺血预处理是否能改善局部昏迷猪心肌缺血后心室功能的恢复。方法采用戊巴比妥麻醉猪开胸麻醉。通过测量节段缩短、脑卒中功、收缩压终末长度关系、预负荷可恢复脑卒中功和预负荷可恢复脑卒中工作面积来监测局部心室功能。对照组患者左冠状动脉前降支闭塞15分钟，再灌注3小时。预处理组接受5分钟左冠状动脉前降支闭塞和10分钟再灌注2个周期，闭塞15分钟。结果两组患者均未发生梗死。预处理方案显著抑制缺血前节段缩短，但不抑制局部脑卒中工作。缺血预处理对局部脑卒中工作、收缩压长度关系、预负荷可负荷脑卒中工作、预负荷可负荷脑卒中工作区域均无显著影响。结论缺血预处理不能改善猪心肌休克，提示缺血预处理在心脏手术中可能具有有限的心脏保护作用。[J]; journal of nurses training; 2009; 17(2): 1 -7。
ObjectiveIschemic preconditioning has been shown to have no beneficial effect on segment shortening in in vivo regionally stunned myocardium. The purpose of this study was to determine whether ischemic preconditioning improves the recovery of postischemic ventricular function when contractility is assessed by load-insensitive measurements including end-systolic pressure length relations, preload recruitable stroke work, and preload recruitable stroke work area in in vivo regionally stunned porcine myocardium.MethodsOpen chest, pentobarbital-anesthetized pigs were used. Regional ventricular function was monitored by measurements of segment shortening, stroke work, end systolic pressure length relations, preload recruitable stroke work, and preload recruitable stroke work area. The control group was submitted to 15 minutes of left anterior descending coronary artery occlusion and 3 hours of reperfusion. The preconditioned group underwent 2 cycles of 5-minute left anterior descending coronary artery occlusion and 10-minute reperfusion before 15 minutes of occlusion.ResultsThere was no infarct in either group. The preconditioning protocol significantly depressed preischemic segment shortening but not regional stroke work. Ischemic preconditioning had no significant beneficial effect on regional stroke work, end-systolic pressure length relations, preload recruitable stroke work, or preload recruitable stroke work area.ConclusionsThese results confirm that ischemic preconditioning does not ameliorate in vivo porcine myocardial stunning and indicate that ischemic preconditioning may have a limited cardioprotective role during cardiac operation. (J Thorac Cardiovasc Surg 1999;117:810-7)
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DOI：
10.1016/0003-4975(94)91940-2
发表时间：
1994
期刊：
The Annals of thoracic surgery
影响因子：
--
作者：
R. Illes;John K. Wright;K. Inners;Chunjie Yang;Adrian Tristan
通讯作者：
Adrian Tristan
血液灌注和缓冲液灌注离体心脏模型缺血预处理的比较。
影响因子：
10.8
作者：
R. Sandhu;R. J. Diaz;G. Wilson
通讯作者：
G. Wilson
影响因子：
3.4
作者：
Cremer, J;Steinhoff, G;Haverich, A
通讯作者：
Haverich, A
在全身缺血的离体大鼠心脏中，通过缺血预处理改善的功能恢复不是由腺苷介导的。
影响因子：
10.8
作者：
A. Cave
通讯作者：
A. Cave
影响因子：
37.8
作者：
M. Ovize;K. Przyklenk;S. Hale;R. Kloner
通讯作者：
R. Kloner