The PCP pathway instructs the planar orientation of ciliated cells in the Xenopus larval skin.
The PCP pathway instructs the planar orientation of ciliated cells in the Xenopus larval skin.
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DOI：
10.1016/j.cub.2009.04.018
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发表时间：
2009-06-09
期刊：
影响因子：
--
通讯作者：
Kintner C
中科院分区：
文献类型：
--
作者：
Mitchell B;Stubbs JL;Huisman F;Taborek P;Yu C;Kintner C
平面细胞极性（PCP）是上皮组织的一种特性，其中细胞结构沿与顶-底极性轴正交的二维平面沿着定向[1]。PCP在多纤毛细胞产生定向流体流动的组织中特别引人注目，例如，在呼吸道或脑室的纤毛上皮细胞中可见。为了产生定向流动，纤毛细胞沿沿着共同的平面轴定向，方向由组织图案设定，但这在任何纤毛上皮中是如何实现的尚不清楚[2]。在这里，我们表明，平面方向ofXenopusmulticiliate细胞被破坏时，在PCP信号通路的组件被改变非细胞自主。我们还表明，野生型纤毛细胞位于突变体克隆边界重定向到低Vangl 2或高Frizzled活性的细胞，远离那些具有高Vangl 2活性。这些结果表明，PCP途径提供了方向性的非细胞自主线索，以定向纤毛细胞，因为他们分化，从而发挥了关键作用，在建立定向纤毛流动。
Planar cell polarity (PCP) is a property of epithelial tissues where cellular structures coordinately orient along a two-dimensional plane lying orthogonal to the axis of apical-basal polarity [1]. PCP is particularly striking in tissues where multiciliate cells generate a directed fluid flow, as seen, for example, in the ciliated epithelia lining the respiratory airways or the ventricles of the brain. To produce directed flow, ciliated cells orient along a common planar axis in a direction set by tissue patterning, but how this is achieved in any ciliated epithelium is unknown [2]. Here, we show that the planar orientation ofXenopusmulticiliate cells is disrupted when components in the PCP-signaling pathway are altered non-cell-autonomously. We also show that wild-type ciliated cells located at a mutant clone border reorient toward cells with low Vangl2 or high Frizzled activity and away from those with high Vangl2 activity. These results indicate that the PCP pathway provides directional non-cell-autonomous cues to orient ciliated cells as they differentiate, thus playing a critical role in establishing directed ciliary flow.
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影响因子：
56.9
作者：
Amonlirdviman, K;Khare, NA;Tomlin, CJ
通讯作者：
Tomlin, CJ
影响因子：
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作者：
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通讯作者：
Mlodzik, Marek
DOI：
10.1038/nrg2125
发表时间：
2007-07
期刊：
Nature reviews. Genetics
影响因子：
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作者：
通讯作者：
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影响因子：
64.8
作者：
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通讯作者：
ADLER, PN