AltitudeOmics: exercise-induced supraspinal fatigue is attenuated in healthy humans after acclimatization to high altitude.
AltitudeOmics: exercise-induced supraspinal fatigue is attenuated in healthy humans after acclimatization to high altitude.
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DOI：
10.1111/apha.12241
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Roach RC
中科院分区：
文献类型：
--
作者：
Goodall S;Twomey R;Amann M;Ross EZ;Lovering AT;Romer LM;Subudhi AW;Roach RC
我们问是否适应慢性缺氧（CH）减弱脊髓上疲劳的水平，在急性缺氧（AH）运动后观察到。7名娱乐活跃的参与者在三种情况下进行相同的恒定负荷自行车（131± 39 W，10.1± 1.4 min）：1）在常氧（N，PIO 2，147.1 mmHg）; 2）在AH（FIO 2，0.105; PIO 2，73.8 mmHg）; 3）在CH（5，260 m; PIO 2，75.7 mmHg）14天后。在整个试验过程中，使用近红外光谱和经颅多普勒超声检查评估前额叶皮层组织氧合和大脑中动脉血流速度（MCAV）。获得运动前和运动后对股神经刺激和经颅磁刺激的抽搐反应，以评估神经肌肉和皮质脊髓功能。AH组静息时（Δ7±5%）和运动终了时（Δ26±13）的前额叶氧合下降（P<0.01），AH组的去氧程度大于N组和CH组（P<0.05）。在运动的最后一分钟，AH组的脑氧输送指数（MCAv× CaO 2）比N组低19±14%（P=0.013），比CH组低20±12%（P=0.040）。在AH和CH中，运动后最大随意和增强的抽搐力低于基线，但N中没有。AH患者运动后皮质自主激活低于基线水平（Δ 11%，P=0.014），但CH（Δ 6%，P=0.174）或N（Δ 4%，P=0.298）患者运动后皮质自主激活低于基线水平。运动诱发电位振幅增加两倍以上的CH相比，AH和N运动后明显。这些数据表明，在AH运动后加剧的脊髓上疲劳在适应海拔14天后减弱。CH中脊髓上疲劳的减少可能归因于皮质脊髓兴奋性增加，从而导致脑O2输送增加。
We asked whether acclimatisation to chronic hypoxia (CH) attenuates the level of supraspinal fatigue that is observed after locomotor exercise in acute hypoxia (AH). Seven recreationally-active participants performed identical bouts of constant-load cycling (131±39W, 10.1±1.4min) on three occasions: 1) in normoxia (N, PIO2, 147.1mmHg); 2) in AH (FIO2, 0.105; PIO2, 73.8mmHg); 3) after 14 days in CH (5,260m; PIO2, 75.7mmHg). Throughout trials, prefrontal-cortex tissue oxygenation and middle cerebral artery blood velocity (MCAV) were assessed using near-infrared-spectroscopy and transcranial Doppler sonography. Pre- and post-exercise twitch responses to femoral nerve stimulation and transcranial magnetic stimulation were obtained to assess neuromuscular and corticospinal function. In AH, prefrontal oxygenation declined at rest (Δ7±5%) and end-exercise (Δ26±13) (P<0.01); the degree of deoxygenation in AH was greater than N and CH (P<0.05). The cerebral O2 delivery index (MCAv×CaO2) was 19±14% lower during the final minute of exercise in AH compared to N (P=0.013) and 20±12% lower compared to CH (P=0.040). Maximum voluntary and potentiated twitch force were decreased below baseline after exercise in AH and CH, but not N. Cortical voluntary activation decreased below baseline after exercise in AH (Δ11%, P=0.014), but not CH (Δ6%, P=0.174) or N (Δ4%, P=0.298). A twofold greater increase in motor evoked potential amplitude was evident after exercise in CH compared to AH and N. These data indicate that exacerbated supraspinal fatigue after exercise in AH is attenuated after 14 days of acclimatisation to altitude. The reduced development of supraspinal fatigue in CH may have been attributable to increased corticospinal excitability, consequent to an increased cerebral O2 delivery.
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影响因子：
3.3
作者：
Amann, Markus;Romer, Lee M.;Dempsey, Jerome A.
通讯作者：
Dempsey, Jerome A.
DOI：
10.1249/00005768-198205000-00012
发表时间：
1982-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
BORG, GAV
通讯作者：
BORG, GAV
影响因子：
9.8
作者：
MAZZEO, RS;WOLFEL, EE;REEVES, JT
通讯作者：
REEVES, JT
影响因子：
2
作者：
Miscio, Giacinta;Milano, Eva;Oliviero, Antonio
通讯作者：
Oliviero, Antonio
影响因子：
2
作者：
Chen, R;Lozano, AM;Ashby, P
通讯作者：
Ashby, P