Fiber in Our Diet and Its Role in Health and Disease
Fiber in Our Diet and Its Role in Health and Disease
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我们饮食中的纤维及其在健康和疾病中的作用
DOI：
10.1007/978-981-13-1123-9_12
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发表时间：
2018
影响因子：
8.8
通讯作者：
S. Seshadri
中科院分区：
文献类型：
--
作者：
Dipeeka K. Mandaliya;Sweta Patel;S. Seshadri
生活方式和饮食习惯直接影响个人的健康，制约着理解不同类型饮食成分的作用。近年来，人们对膳食纤维进行了全面的研究，以了解其在预防心脏病、肥胖、糖尿病、癌症等方面的作用。膳食纤维通过其发酵产物(主要是短链脂肪酸)直接向肠道微生物区系提供营养，并间接向肠上皮细胞提供营养。膳食纤维的摄入改变了肠道微生物区系，其发酵产物主要是短链脂肪酸，通过维持能量平衡和免疫反应来调节疾病状态。膳食纤维可降低血清低密度脂蛋白、胆固醇和血压，预防心脏病。膳食纤维的摄入还有助于通过诱导饱腹感信号来减少BMI，并提供肥胖效应。单链脂肪酸通过GPCR型受体作用于不同的组织，调节疾病状态。在肥胖和糖尿病的情况下，SCFA通过肠-脑轴改善胰岛素分泌和血糖稳态。
Lifestyle and dietary habits directly influence the health of an individual constraining to understand the role of different types of diet components. Recently, dietary fibers are being studied comprehensively to understand its role in prevention of heart diseases, obesity, diabetes, cancer, etc. Dietary fibers provide nutrition to the gut microbiota directly and to intestinal epithelial cells indirectly via its fermentation products mainly short-chain fatty acids (SCFAs). Dietary fiber consumption alters gut microbiota, and its fermentation product mainly short-chain fatty acids modulates disease condition by maintaining energy homeostasis and immune response. Dietary fibers reduce serum LDL cholesterol and blood pressure preventing heart diseases. Dietary fiber consumption also helps in reducing BMI via inducing satiety signals and provides bulking effect. SCFAs act on different tissues via GPCR receptors and modulate disease condition. In case of obesity and diabetes, SCFA improves insulin secretion and glucose homeostasis via gut-brain axis.
影响因子：
29
作者：
Donohoe DR;Garge N;Zhang X;Sun W;O'Connell TM;Bunger MK;Bultman SJ
通讯作者：
Bultman SJ
影响因子：
7.1
作者：
Ma, YS;Griffith, JA;Ockene, IS
通讯作者：
Ockene, IS