Sensory coding accuracy and perceptual performance are improved during the desynchronized cortical state.
Sensory coding accuracy and perceptual performance are improved during the desynchronized cortical state.
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DOI：
10.1038/s41467-017-01030-4
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发表时间：
2017-11-03
影响因子：
16.6
通讯作者：
Dragoi V
中科院分区：
文献类型：
--
作者：
Beaman CB;Eagleman SL;Dragoi V
大脑皮层活动在一天中持续变化。在全球范围内，种群活动在睡眠期间的“已同步”状态和在唤醒期间的“去同步”状态之间变化。然而，清醒时群体同步性的局部波动是否会调节感觉编码和行为表现的准确性，目前还知之甚少。在这里，我们发现猴子视皮层中的细胞群体在同步性方面表现出快速波动，从指示高警觉性的去同步反应到高度同步反应。这些波动是局部的，并控制在辨别任务中群体编码准确性和行为表现的试验变异性。当局部种群活动被去同步时，神经元之间的相关变异性被降低，网络和行为性能被增强。这些发现表明，局部皮质种群的可变性结构不是噪声，而是控制感觉信息如何与正在进行的过程最佳地整合，以指导网络编码和行为。在整个睡眠-觉醒周期中观察到大脑皮层群体同步性的变化，然而，觉醒期间同步性波动的影响尚不清楚。在这里，作者表明，视觉皮层神经元提高了感觉编码的准确性，并在局部群体去同步化期间改善了感知性能。
Cortical activity changes continuously during the course of the day. At a global scale, population activity varies between the ‘synchronized’ state during sleep and ‘desynchronized’ state during waking. However, whether local fluctuations in population synchrony during wakefulness modulate the accuracy of sensory encoding and behavioral performance is poorly understood. Here, we show that populations of cells in monkey visual cortex exhibit rapid fluctuations in synchrony ranging from desynchronized responses, indicative of high alertness, to highly synchronized responses. These fluctuations are local and control the trial variability in population coding accuracy and behavioral performance in a discrimination task. When local population activity is desynchronized, the correlated variability between neurons is reduced, and network and behavioral performance are enhanced. These findings demonstrate that the structure of variability in local cortical populations is not noise but rather controls how sensory information is optimally integrated with ongoing processes to guide network coding and behavior. Changes in synchrony of cortical populations are observed across the sleep-wake cycle, however the effect of fluctuations in synchrony during wakefulness is not understood. Here the authors show that visual cortical neurons have improved sensory encoding accuracy as well as improved perceptual performance during periods of local population desynchrony.
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影响因子：
25
作者：
Goris, Robbe L. T.;Movshon, J. Anthony;Simoncelli, Eero P.
通讯作者：
Simoncelli, Eero P.
影响因子：
16.2
作者：
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Tolias AS
影响因子：
9.2
作者：
Erisken, Sinem;Vaiceliunaite, Agne;Busse, Laura
通讯作者：
Busse, Laura