Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease.
Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease.
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DOI：
10.1038/s41598-018-25377-w
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发表时间：
2018-05-10
影响因子：
4.6
通讯作者：
Doraiswamy PM
中科院分区：
文献类型：
--
作者：
Sohn D;Shpanskaya K;Lucas JE;Petrella JR;Saykin AJ;Tanzi RE;Samatova NF;Doraiswamy PM
阿尔茨海默病 (AD) 生物学和进展中的性别差异尚未得到充分表征。本研究的目的是检查性别对因阿尔茨海默病而患有轻度认知障碍 (MCI) 的可能性较高的受试者认知进展的影响，并在阿尔茨海默病神经影像计划 (ADNI) 中进行长达 10 年的随访。脑脊液总 tau 蛋白和淀粉样蛋白 - β (Aβ42) 比率值用于将 559 名 MCI 受试者（216 名女性，343 名男性）细分为因阿尔茨海默病而患 MCI 的可能性“高”或“低”。使用包含所有后续行动的混合效应模型对数据进行分析。阿尔茨海默病评估量表-认知评分（平均值，SD）（9±±12）较基线恶化程度，因阿尔茨海默病而发生 MCI 的可能性较高的受试者明显大于可能性较低的受试者（1±±6，p<0.0001）。在 AD 引起的 MCI 受试者中，女性认知评分平均恶化 (11.58±14) 显着高于男性 (6.87±11，p=0.006)。我们的研究结果强调需要在其他人群中进一步研究这些发现，并制定阿尔茨海默病进展的性别特异性时间表。
Sex differences in Alzheimer’s disease (AD) biology and progression are not yet fully characterized. The goal of this study is to examine the effect of sex on cognitive progression in subjects with high likelihood of mild cognitive impairment (MCI) due to Alzheimer’s and followed up to 10 years in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Cerebrospinal fluid total-tau and amyloid-beta (Aβ42) ratio values were used to sub-classify 559 MCI subjects (216 females, 343 males) as having “high” or “low” likelihood for MCI due to Alzheimer’s. Data were analyzed using mixed-effects models incorporating all follow-ups. The worsening from baseline in Alzheimer’s Disease Assessment Scale-Cognitive score (mean, SD) (9 ± 12) in subjects with high likelihood of MCI due to Alzheimer’s was markedly greater than that in subjects with low likelihood (1 ± 6, p < 0.0001). Among MCI due to AD subjects, the mean worsening in cognitive score was significantly greater in females (11.58 ± 14) than in males (6.87 ± 11, p = 0.006). Our findings highlight the need to further investigate these findings in other populations and develop sex specific timelines for Alzheimer’s disease progression.
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影响因子：
4.2
作者：
Atluri, Gowtham;Padmanabhan, Kanchana;Fang, Gang;Steinbach, Michael;Petrella, Jeffrey R.;Lim, Kelvin;MacDonald, Angus, III;Samatova, Nagiza F.;Doraiswamy, P. Murali;Kumar, Vipin
通讯作者：
Kumar, Vipin
影响因子：
5.7
作者：
Reuter, Martin;Schmansky, Nicholas J.;Rosas, H. Diana;Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
2.1
作者：
Bretsky, PM;Buckwalter, JG;Henderson, VW
通讯作者：
Henderson, VW
影响因子：
9.9
作者：
Seshadri, S;Wolf, PA;D'Agostino, RB
通讯作者：
D'Agostino, RB
影响因子：
3.7
作者：
Lampert EJ;Roy Choudhury K;Hostage CA;Petrella JR;Doraiswamy PM;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative