Blood glucose concentration and risk of liver cancer: systematic review and meta-analysis of prospective studies.
Blood glucose concentration and risk of liver cancer: systematic review and meta-analysis of prospective studies.
复制标题
血糖浓度和肝癌的风险：前瞻性研究的系统评价和荟萃分析。
DOI：
10.18632/oncotarget.16816
复制
发表时间：
2017-07-25
期刊：
影响因子：
--
通讯作者：
He J
中科院分区：
文献类型：
--
作者：
Han H;Zhang T;Jin Z;Guo H;Wei X;Liu Y;Chen Q;He J
血糖升高是否是肝癌的危险因素的问题已经得到了深入的研究，但结果并不一致。为了探讨血糖浓度与肝癌风险之间的关系，我们进行了前瞻性研究的荟萃分析。使用PubMed、EMBASE和Cochrane图书馆数据库进行综合文献检索，检索至2016年10月。使用随机效应模型合并效应估计。纳入文献8篇，共10篇研究，共1975例肝癌病例。合并RRS显示，空腹血糖升高与患肝癌的风险增加相关(合并RRS：1.77；95%CI：1.46，2.13)，且存在轻度异质性(I2=30.40%，P=0.17)。在敏感性分析中，当我们将血糖类别限制在非糖尿病受试者的范围内时，合并结果仍然显著(合并RRS：1.33；95%CI：1.12，1.59；I2=33.90%，P=0.16)。我们还检测到血糖浓度与肝癌风险之间存在J型非线性剂量-反应关系。有证据表明，在糖尿病前期和糖尿病范围内，血糖升高会增加患肝癌的风险。考虑到糖尿病前期和糖尿病患病率的迅速上升，控制血糖可能会降低患肝癌的风险。
The question of whether elevated blood glucose is a risk factor for liver cancer has been intensively studied, yet with inconsistent results. To explore the relationship between blood glucose concentration and risk of liver cancer, we conduct a meta-analysis of prospective studies. Literature search was comprehensively performed using database of PubMed, EMBASE and the Cochrane Library through October 2016. Random-effect models were used to combine the effect estimations. Eight articles containing ten studies with a total of 1975 liver cancer cases were included. The pooled RRs demonstrated that elevated fasting blood glucose was associated with increased risk of liver cancer (combined RRs: 1.77; 95% CI: 1.46, 2.13) with mild heterogeneity (I2 = 30.40%, P = 0.17). In sensitivity analysis, the pooled result remained significant (combined RRs: 1.33; 95% CI: 1.12, 1.59; I2 = 33.90%, P = 0.16) when we restricted blood glucose categories in the range of nondiabetic subjects. We also detected a J-shaped non-linear dose-response relationship between blood glucose concentration and risk of liver cancer. There is evidence that elevated blood glucose increases risk of liver cancer across the range of prediabetes and diabetes. Considering the rapidly increasing prevalence of prediabetes and diabetes, controlling blood glucose may lower the risk of liver cancer.
登录
查看更多内容
影响因子：
3.7
作者：
Papa S;Bubici C;Zazzeroni F;Franzoso G
通讯作者：
Franzoso G
吸烟是肝细胞癌的独立危险因素：新加坡中国卫生研究。
影响因子：
8.8
作者：
Koh, W-P;Robien, K.;Wang, R.;Govindarajan, S.;Yuan, J-M;Yu, M. C.
通讯作者：
Yu, M. C.
影响因子：
5.1
作者：
McGlynn KA;Petrick JL;London WT
通讯作者：
London WT
影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
16.2
作者：
通讯作者：
--