Improvement of brain function after surgery in infants with posterior quadrant cortical dysplasia
Improvement of brain function after surgery in infants with posterior quadrant cortical dysplasia
复制标题
后象限皮质发育不良婴儿术后脑功能的改善
DOI：
10.1016/j.clinph.2020.11.020
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发表时间：
2021
影响因子：
4.7
通讯作者：
Sasaki Masayuki
中科院分区：
文献类型：
--
作者：
Ueda Riyo;Iwasaki Masaki;Kita Yosuke;Takeichi Hiroshige;Saito Takashi;Nakagawa Eiji;Sugai Kenji;Okada Takashi;Sasaki Masayuki
目的探讨脑电图（EEG）功能连接分析能否定量评估癫痫手术后婴儿的神经发育结果。方法我们纳入了13例年龄<2岁的后象限发育不良婴儿，采用后象限切除术治疗，并与21例年龄匹配的婴儿进行比较。术前及术后1年均行EEG检查。术前及术后3年分别进行发育商（DQ）测定。非手术半球中三对不同电极的相位滞后指数（PLI），即，计算前短距离（ASD）、后短距离（PSD）和长距离（LD）对作为脑连接性的指数。PLI和DQ之间的关系进行了evaluated.ResultsOverall，77%的婴儿经历了癫痫发作的自由手术后。PSD对的β和γ范围PLI在术前增加。所有这些对术后恢复正常。简单的线性回归分析显示，术后DQ和术后β带PLI的ASD pairs.ConclusionPreoperative异常hyperconnectivity手术后正常化的控制水平之间的显着关系。术后超连接与长期神经发育改善相关。
ObjectiveTo reveal whether neurodevelopmental outcome of infants after epilepsy surgery can be quantitatively assessed by electroencephalography (EEG) functional connectivity analysis.MethodsWe enrolled 13 infants with posterior quadrant dysplasia aged <2 years who were treated using posterior quadrantectomy and 21 age-matched infants. EEG was performed both before and one year after surgery. Developmental quotient (DQ) was assessed both before and 3 years after surgery. The phase lag index (PLI) of three different pairs of electrodes in the nonsurgical hemisphere, i.e., the anterior short distance (ASD), posterior short distance (PSD), and long distance (LD) pairs, were calculated as indices of brain connectivity. The relationship between the PLI and DQ was evaluated.ResultsOverall, 77% infants experienced seizure freedom after surgery. The beta- and gamma- range PLI of PSD pairs increased preoperatively. All these pairs normalized postoperatively. Simple linear regression analysis revealed a significant relationship between the postoperative DQ and the postoperative beta-band PLI of ASD pairs.ConclusionPreoperative abnormal hyper-connectivity was normalized to the control level after surgery. The postoperative hyperconnectivity was associated with long-term neurodevelopmental improvement.SignificancePLI quantifies neurodevelopmental improvements after posterior quadrantectomy.
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影响因子：
5.6
作者：
Kalbhenn, Thilo;Cloppenborg, Thomas;Bien, Christian G.
通讯作者：
Bien, Christian G.
后象限癫痫的断开手术：一系列 12 名儿科患者。
DOI：
10.1684/epd.2014.0678
发表时间：
2014
期刊：
Epileptic disorders : international epilepsy journal with videotape
影响因子：
--
作者：
Pengfan Yang;Zhen Mei;Q. Lin;Jiasheng Pei;Hui;Zhonghui Zhong;Jun Tian;Yanzeng Jia;Zi;Zhi
通讯作者：
Zhi
后象限发育不良或半侧巨脑畸形
影响因子：
9.9
作者：
Maria Daniela D'Agostino;A. Bastos;C. Piras;A. Bernasconi;T. Grisar;V. G. Tsur;J. Snipes;C. Juhász;H. Chugani;R. Guerrini;Helen Cross;E. Andermann;François Dubeau;José L. Montes;André Olivier;Frederick Andermann
通讯作者：
Frederick Andermann
从新生儿到婴儿期脑电图睡眠的个体发育。
影响因子：
4.8
作者：
Scher,MarkS
通讯作者：
Scher,MarkS
使用视频脑电图监测智障儿童的癫痫发作模仿者
影响因子：
2.6
作者：
Riyo Ueda;Y. Shimizu;K. Sugai;E. Takeshita;A. Ishiyama;Takashi Saito;H. Komaki;E. Nakagawa;M. Sasaki
通讯作者：
M. Sasaki