Early prediction of necrotizing pneumonia from mycoplasma pneumoniae pneumonia with large pulmonary lesions in children.
Early prediction of necrotizing pneumonia from mycoplasma pneumoniae pneumonia with large pulmonary lesions in children.
复制标题
儿童肺部大病灶肺炎支原体肺炎早期预测坏死性肺炎
DOI：
10.1038/s41598-020-76083-5
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发表时间：
2020-11-04
影响因子：
4.6
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Zhou Y;Hu M;Ye B;Chen Z;Zhang Y
比较肺炎支原体肺炎（MPP）所致伴有大片肺部病变的坏死性肺炎（NP）与非坏死性肺炎（NNP）的不同特征，并探寻能区分NP与MPP的预测指标。回顾性研究2008年1月至2019年12月期间住院的伴有大片肺部病变的MPP患者，分析其临床表现、实验室检查结果及影像学表现。在135例伴有大片肺部病变的MPP患者中，56例为NP组，79例为NNP组。我们发现NP组发热天数的中位数比NNP组长得多。观察到NP组白细胞（WBC）、C反应蛋白（CRP）、乳酸脱氢酶（LDH）、白细胞介素-6（IL-6）水平更高。此外，NP患者肺部实变的发生率比NNP患者高得多，而NP患者大片肺部病变的CT值则低得多。在受试者工作特征（ROC）曲线分析中，CT值和干扰素-γ（IFN-γ）的临界值分别为36.43和7.25皮克/毫升。MPP所致的NP可能更容易出现病程迁延，以及严重的实验室和影像学表现。大片肺部病变的CT值和IFN-γ可作为生物标志物，用于预测儿童伴有大片肺部病变的MPP是否发展为NP。
To compare the different features of necrotizing pneumonia (NP) and non-NP (NNP) caused by Mycoplasma pneumoniae pneumonia (MPP) with large pulmonary lesions, and explore the predictor for NP to differentiate from MPP. A retrospective study of MPP patients with large pulmonary lesions hospitalized from January 2008 to December 2019 was enrolled, and clinical manifestations, laboratory findings, radiological findings were analyzed. Of 135 MPP patients with large pulmonary lesions, 56 were in the NP group, 79 were in the NNP group. We found the median length of fever days were much longer in NP group than those in NNP group. Higher levels of WBC, CRP, LDH, IL-6 in NP group were observed. Furthermore, the incidence of pulmonary consolidation was much higher in NP patients than that in NNP patients, while the CT value of large pulmonary lesion was much lower in NP patients. In ROC curve analysis, the cut-off values for the CT value and IFN-γ were 36.43 and 7.25 pg/ml, respectively. NP caused by MPP might be easier to suffer from prolonged clinical course, severe laboratory and radiological findings. CT value of large pulmonary lesions and IFN-γ could be used as biomarkers to predict NP from MPP with large pulmonary lesions in children.
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影响因子：
1.4
作者：
Uehara, Suzuko;Sunakawa, Keisuke;Yamazaki, Tsutomu
通讯作者：
Yamazaki, Tsutomu
影响因子：
4.9
作者：
Zhou, Yunlian;Zhang, Yuanyuan;Chen, Zhimin
通讯作者：
Chen, Zhimin
影响因子：
8.7
作者：
Wang, Xia;Zhong, Li-Jia;Zhang, Yuan-Yuan
通讯作者：
Zhang, Yuan-Yuan
影响因子：
3.6
作者：
Chiu, CY;Chiang, LM;Chen, TP
通讯作者：
Chen, TP
影响因子：
4.9
作者：
Suzuki, S;Yamazaki, T;Sasaki, T
通讯作者：
Sasaki, T