Experimental study of negative pressure wound therapy combined with platelet-rich fibrin for bone-exposed wounds.
Experimental study of negative pressure wound therapy combined with platelet-rich fibrin for bone-exposed wounds.
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负压创面疗法联合富血小板纤维蛋白治疗骨外露创面的实验研究
DOI：
10.2217/rme-2021-0043
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发表时间：
2021-12
影响因子：
2.7
通讯作者：
Wang Biao
中科院分区：
文献类型：
--
作者：
Zhang Hong;Wang Songyu;Lei Chen;Li Guanmin;Wang Biao
目的评价负压创伤疗法(NPWT)联合富血小板纤维蛋白(PRF)治疗骨暴露创面的疗效，并探讨其可能的作用机制。材料与方法32只健康SD大鼠，随机分为对照组、NPWT组、PRF组和两者(N+P组)。分别于第4、7、10天测定创面裸露面积、皮肤收缩率、肉芽覆盖率及肉芽组织中生长因子水平。结果N+P组创面愈合率明显高于其他组。结论NPWT与PRF联合应用能有效修复骨外露创面，促进创面愈合。
AimTo evaluate the efficacy of negative pressure wound therapy (NPWT) combined with platelet-rich fibrin (PRF) in treating bone-exposed wounds and explore its possible mechanism.Materials & methodsA bone-exposed wound was created in a total of 32 healthy Sprague-Dawley rats, which were divided into either control group, NPWT group, PRF group or both (N + P group). The bone-exposed area, skin contraction rate and granulation coverage and the level of growth factors in granulation tissue were determined on days 4, 7 and 10.ResultsThe N + P group showed significantly higher wound closure rate than that achieved with others respectively. Four factors were significantly higher in N + P group than in the other three groups.ConclusionCombination of NPWT and PRF can repair bone-exposed wounds effectively and accelerate wound healing.
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影响因子：
4.6
作者：
Cowan, KN;Teague, L;Mahoney, JL
通讯作者：
Mahoney, JL
影响因子：
17.1
作者：
Eming SA;Martin P;Tomic-Canic M
通讯作者：
Tomic-Canic M
DOI：
--
发表时间：
2008
期刊：
--
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.6
作者：
Broughton, George 2nd;Janis, Jeffrey E;Attinger, Christopher E
通讯作者：
Attinger, Christopher E
影响因子：
--
作者：
S. Powis;T. Waterworth;D. Arkell
通讯作者：
S. Powis;T. Waterworth;D. Arkell