Increasing the reproducibility of fluid biomarker studies in neurodegenerative studies.
Increasing the reproducibility of fluid biomarker studies in neurodegenerative studies.
复制标题
DOI：
10.1038/s41467-020-19957-6
复制
发表时间：
2020-12-07
影响因子：
16.6
通讯作者：
Hansson O
中科院分区：
文献类型：
--
作者：
Mattsson-Carlgren N;Palmqvist S;Blennow K;Hansson O
生物标志物彻底改变了神经退行性疾病（特别是阿尔茨海默病）的科学研究，改变了药物试验设计，并且也日益改善了临床实践中的患者管理。一些关键的脑脊液生物标志物与神经退行性疾病密切相关。几种新型生物标志物非常有前途，尤其是基于血液的标志物。然而，尽管最初的结果很有希望，但许多生物标志物的发现重复性较低。从这个角度来看，我们确定了神经退行性疾病液体生物标志物研究重复性低的可能来源，重点关注阿尔茨海默病。我们为研究人员和期刊编辑提出指南，旨在提高研究结果的可重复性。尽管最初的结果很有希望，但许多液体生物标志物的研究结果的重复性较低。在这里，作者回顾了神经退行性疾病液体生物标志物研究重复性低的可能来源，并提出了供生物标志物界商定和实施的指南。
Biomarkers have revolutionized scientific research on neurodegenerative diseases, in particular Alzheimer’s disease, transformed drug trial design, and are also increasingly improving patient management in clinical practice. A few key cerebrospinal fluid biomarkers have been robustly associated with neurodegenerative diseases. Several novel biomarkers are very promising, especially blood-based markers. However, many biomarker findings have had low reproducibility despite initial promising results. In this perspective, we identify possible sources for low reproducibility of studies on fluid biomarkers for neurodegenerative diseases, with a focus on Alzheimer’s disease. We suggest guidelines for researchers and journal editors, with the aim to improve reproducibility of findings. Many fluid biomarker findings have had low reproducibility despite initially promising results. Here, the authors review possible sources for low reproducibility of studies on fluid biomarkers for neurodegenerative diseases and suggest guidelines for the biomarker community to agree on and implement.
登录
查看更多内容
影响因子：
9.9
作者：
Benedict, Christian;Blennow, Kaj;Cedernaes, Jonathan
通讯作者：
Cedernaes, Jonathan
影响因子：
9
作者：
Bertens, Daniela;Tijms, Betty M.;Visser, Pieter Jelle
通讯作者：
Visser, Pieter Jelle
影响因子：
3.4
作者：
Chang, Chun-Wei;Yang, Shieh-Yueh;Wu, Yih-Ru
通讯作者：
Wu, Yih-Ru
影响因子：
11.2
作者：
Benatar, Michael;Wuu, Joanne;Malaspina, Andrea
通讯作者：
Malaspina, Andrea
影响因子：
3.7
作者：
Bjorkqvist, Maria;Ohlsson, Mattias;Hansson, Oskar
通讯作者：
Hansson, Oskar