The vacuole guard hypothesis: how intravacuolar pathogens fight to maintain the integrity of their beloved home.
The vacuole guard hypothesis: how intravacuolar pathogens fight to maintain the integrity of their beloved home.
复制标题
DOI：
10.1016/j.mib.2020.01.008
复制
发表时间：
2020-04
影响因子：
5.4
通讯作者：
Isberg RR
中科院分区：
文献类型：
--
作者：
Anand I;Choi W;Isberg RR
孔内细菌病原体通过构建膜包裹的室来建立细胞内的生态位。细菌周围的液泡非常稳定，有利于微生物复制，防止暴露于宿主细胞质定位的先天免疫感应机制。为了保持膜室的完整性，病原体配备了防御武器，以防止液泡完整性的丧失和潜在的暴露于宿主先天信号。在某些情况下，维持液泡完整性的微生物成分已被确定，但在没有它们的情况下，隔间降解的基础尚不清楚。在这篇综述中，我们指出，细胞质定位的福氏志贺氏菌对液泡的微生物程序化降解的经验教训为病原体液泡如何降解提供了重要的见解。我们提出，在缺乏细菌编码的保护蛋白的情况下，宿主膜相关成分的异常运输导致病原体室功能失调。结果，液泡被毒害，复制被终止。
Intravacuolar bacterial pathogens establish intracellular niches by constructing membrane-encompassed compartments. The vacuoles surrounding the bacteria are remarkably stable, facilitating microbial replication and preventing exposure to host cytoplasmically-localized innate immune sensing mechanisms. To maintain integrity of the membrane compartment, the pathogen is armed with defensive weapons that prevent loss of vacuole integrity and potential exposure to host innate signaling. In some cases, the microbial components that maintain vacuolar integrity have been identified, but the basis for why the compartment degrades in their absence is unclear. In this review, we point out that lessons from the microbial-programmed degradation of the vacuole by the cytoplasmically-localized Shigella flexneri provide critical insights into how degradation of pathogen vacuoles occurs. We propose that in the absence of bacterial-encoded guard proteins, aberrant trafficking of host membrane-associated components results in a dysfunctional pathogen compartment. As a consequence, the vacuole is poisoned and replication is terminated.
登录
查看更多内容
DOI：
10.1126/science.1227026
发表时间：
2012-11-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Choy A;Dancourt J;Mugo B;O'Connor TJ;Isberg RR;Melia TJ;Roy CR
通讯作者：
Roy CR
影响因子：
6.4
作者：
McDonough JA;Newton HJ;Klum S;Swiss R;Agaisse H;Roy CR
通讯作者：
Roy CR
影响因子：
6.7
作者：
Derré I;Swiss R;Agaisse H
通讯作者：
Agaisse H
影响因子：
6.7
作者：
Lopez-Jimenez, Ana T.;Cardenal-Munoz, Elena;Soldati, Thierry
通讯作者：
Soldati, Thierry
影响因子：
3.4
作者：
Anand, Ila S.;Choi, Wonyoung;Isberg, Ralph R.
通讯作者：
Isberg, Ralph R.