Dopamine and gamma band synchrony in schizophrenia--insights from computational and empirical studies.
Dopamine and gamma band synchrony in schizophrenia--insights from computational and empirical studies.
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DOI：
10.1111/j.1460-9568.2012.08071.x
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Cho RY
中科院分区：
文献类型：
--
作者：
Kömek K;Bard Ermentrout G;Walker CP;Cho RY
多巴胺通过作用于gaba能中间神经元来调节皮层回路活动，包括增加快速脉冲中间神经元的兴奋性。虽然这种作用已经在单细胞中得到证实，但还没有研究表明这种机制如何在神经网络水平上导致多巴胺的作用。基于这一动机，我们研究了多巴胺对由兴奋性和快速尖峰抑制性Wang-Buzsaki神经元组成的模拟神经网络同步的影响。多巴胺的作用是通过改变快速尖峰中间神经元的泄漏K+电导来实现的，并分析了伽马波段（~40 Hz）内的网络同步。参数化变化泄漏K+电导呈现倒u型关系，在低和高电导水平下伽马带功率都较低，在中等电导水平下同步最佳。我们还研究了调节抑制性神经元兴奋性的效果，更一般地使用一个理想化的模型与θ神经元，有类似的发现。此外，当外部输入是强音输入还是周期性输入时，这种关系都成立。我们的计算结果反映了我们对精神分裂症和健康对照中多巴胺调节的实证研究，该研究表明，安非他明增加了患者的伽马功率，但降低了对照组的伽马功率。总之，我们的计算和实证研究表明，多巴胺可以以倒u型方式调节皮质伽马带同步，并且多巴胺对单个快速尖峰中间神经元的生理效应可以在网络水平上引起这种非单调效应。
Dopamine modulates cortical circuit activity, in part, through its actions on GABAergic interneurons, including increasing the excitability of fast-spiking interneurons. Though such effects have been demonstrated in single cells, there are no studies that examine how such mechanisms may lead to the effects of dopamine at a neural network level. With this motivation, we investigated the effects of dopamine on synchronization in a simulated neural network, composed of excitatory and fast-spiking inhibitory Wang-Buzsaki neurons. The effects of dopamine were implemented through varying leak K+ conductance of the fast-spiking interneurons and the network synchronization within gamma band (~40 Hz) was analyzed. Parametrically varying the leak K+ conductance revealed an inverted-U shaped relationship, with low gamma band power at both low and high conductance levels, and optimal synchronization at intermediate conductance levels. We also examined the effects of modulating excitability of the inhibitory neurons more generically using an idealized model with theta neurons, with similar findings. Moreover, such relationship holds both when the external input is tonic vs. periodic. Our computational results mirror our empirical study of dopamine modulation in schizophrenia and healthy controls, which showed that amphetamine administration increased gamma power in patients but decreased it in controls. Together, our computational and empirical investigations indicate that dopamine can modulate cortical gamma band synchrony in an inverted-U fashion, and that the physiologic effects of dopamine on single fast-spiking interneurons can give rise to such non-monotonic effects at the network level.
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影响因子：
2.9
作者：
Ermentrout, B
通讯作者：
Ermentrout, B
DOI：
10.1073/pnas.0609440103
发表时间：
2006-12-26
影响因子：
11.1
作者：
Cho, R. Y.;Konecky, R. O.;Carter, C. S.
通讯作者：
Carter, C. S.
影响因子：
1.2
作者：
Brunel, N;Wang, XJ
通讯作者：
Wang, XJ
影响因子：
17.7
作者：
Akil, M;Pierri, JN;Lewis, DA
通讯作者：
Lewis, DA
影响因子：
2.9
作者：
Börgers, C;Kopell, N
通讯作者：
Kopell, N