Control of aging by the renin-angiotensin system: a review of C. elegans, Drosophila, and mammals.
Control of aging by the renin-angiotensin system: a review of C. elegans, Drosophila, and mammals.
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DOI：
10.3389/fphar.2022.938650
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发表时间：
2022
影响因子：
5.6
通讯作者：
Kornfeld, Kerry
中科院分区：
文献类型：
--
作者：
Egan, Brian M.;Scharf, Andrea;Pohl, Franziska;Kornfeld, Kerry
关键词：
自由生活的非寄生线虫秀丽隐杆线虫是研究衰老和长寿的首要模式生物，因为它的寿命短，强大的遗传工具，以及哺乳动物基本机制的保护。大约70%的人类基因在C.包括许多在影响衰老的途径中编码蛋白质的线虫。在C.在影响寿命的线虫中，包括饮食限制途径、胰岛素/胰岛素样生长因子（IGF）信号传导途径和线粒体电子传递链组分的破坏。C.秀丽隐杆线虫也是一个强大的药物筛选系统，已经报道了许多延长寿命的化合物;值得注意的是，几种FDA批准的药物延长了秀丽隐杆线虫的寿命。elegans，提高了它们也可以延长人类寿命的可能性。哺乳动物中的肾素-血管紧张素系统（RAS）是一种调节血压的内分泌系统和一种在广泛组织中起作用以控制生理过程的旁分泌系统;它是降低血压药物的常用靶标，包括血管紧张素转换酶（ACE）抑制剂和血管紧张素II受体阻滞剂（ARB）。新出现的证据表明，这一系统会影响衰老。In C.在线虫中，降低ACE同系物acn-1的活性或用ACE抑制剂Captopril治疗显著延长寿命。在果蝇中，用ACE抑制剂治疗可以延长寿命。在啮齿类动物中，通过遗传或药物干预来操纵RAS可以延长寿命。在人类中，ACE基因的多态性与极端长寿有关。这些结果表明RAS在控制寿命方面起着保守的作用。在这里，我们回顾RAS和衰老的研究，强调C。线虫作为理解寿命控制机制的模型。
The free-living, non-parasitic nematode Caenorhabditis elegans is a premier model organism for the study of aging and longevity due to its short lifespan, powerful genetic tools, and conservation of fundamental mechanisms with mammals. Approximately 70 percent of human genes have homologs in C. elegans, including many that encode proteins in pathways that influence aging. Numerous genetic pathways have been identified in C. elegans that affect lifespan, including the dietary restriction pathway, the insulin/insulin-like growth factor (IGF) signaling pathway, and the disruption of components of the mitochondrial electron transport chain. C. elegans is also a powerful system for performing drug screens, and many lifespan-extending compounds have been reported; notably, several FDA-approved medications extend the lifespan in C. elegans, raising the possibility that they can also extend the lifespan in humans. The renin–angiotensin system (RAS) in mammals is an endocrine system that regulates blood pressure and a paracrine system that acts in a wide range of tissues to control physiological processes; it is a popular target for drugs that reduce blood pressure, including angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs). Emerging evidence indicates that this system influences aging. In C. elegans, decreasing the activity of the ACE homolog acn-1 or treatment with the ACE-inhibitor Captopril significantly extends the lifespan. In Drosophila, treatment with ACE inhibitors extends the lifespan. In rodents, manipulating the RAS with genetic or pharmacological interventions can extend the lifespan. In humans, polymorphisms in the ACE gene are associated with extreme longevity. These results suggest the RAS plays a conserved role in controlling longevity. Here, we review studies of the RAS and aging, emphasizing the potential of C. elegans as a model for understanding the mechanism of lifespan control.
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血管紧张素转换酶（ACE）基因gambiae的基因家族。
影响因子：
4.4
作者：
Burnham, Susan;Smith, Judith A;Lee, Alison J;Isaac, R Elwyn;Shirras, Alan D
通讯作者：
Shirras, Alan D
影响因子：
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DOI：
10.1093/gerona/glr223
发表时间：
2012-04-01
影响因子：
5.1
作者：
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通讯作者：
Perls, Thomas T.
DOI：
10.1152/ajpheart.00393.2007
发表时间：
2007-09-01
影响因子：
4.8
作者：
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通讯作者：
Inserra, Felipe
影响因子：
8.3
作者：
Assayag, P;Charlemagne, D;Besse, S
通讯作者：
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