Tuberculosis treatment adherence in the era of COVID-19.
Tuberculosis treatment adherence in the era of COVID-19.
复制标题
结核病治疗在Covid-19时代的依从性。
DOI：
10.1186/s12879-022-07787-4
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发表时间：
2022-10-26
影响因子：
3.7
通讯作者：
Shah, Maunank
中科院分区：
文献类型：
--
作者：
Lippincott, Christopher;Perry, Allison;Munk, Elizabeth;Maltas, Gina;Shah, Maunank
在美国，直接观察治疗（DOT）通常用于结核病（TB）治疗监测，视频DOT（vDOT）的使用越来越多。我们评估了COVID-19对结核病治疗依从性以及vDOT的利用和有效性的影响。我们提取了2019年4月至2021年4月期间在马里兰州巴尔的摩接受结核病治疗的个人的常规收集数据。我们的主要结果是评估vDOT的使用和治疗依从性，定义为通过观察（面对面与视频DOT）验证的处方剂量（每周7天）的比例，比较COVID前和COVID（2020年4月）期间的个体。在52名结核病患者中，24人（46%）在COVID-19大流行期间接受了治疗。与COVID前（12/28[43%]，p = 0.02）相比，COVID期间（18/24[75%]）的vDOT利用率显著增加。总体而言，COVID前和COVID期间的中位验证依从性相似（分别为65%和68%，p = 0.96）。与DOT（中位数59% [IQR 55-64%]，p < 0.01）相比，使用vDOT（中位数86% [IQR 70-98%]）时的依从性总体上显著更高; vDOT的依从性改善在COVID前（中位数98% vs. 58%，p < 0.01）和COVID期间（中位数80% vs. 62%，p = 0.01）都很明显。vDOT的使用在COVID期间增加，并且在验证处方治疗的摄入方面比亲自DOT更有效。
In-person directly observed therapy (DOT) is commonly used for tuberculosis (TB) treatment monitoring in the US, with increasing usage of video-DOT (vDOT). We evaluated the impact of COVID-19 on TB treatment adherence, and utilization and effectiveness of vDOT. We abstracted routinely collected data on individuals treated for TB disease in Baltimore, Maryland between April 2019 and April 2021. Our primary outcomes were to assess vDOT utilization and treatment adherence, defined as the proportion of prescribed doses (7 days/week) verified by observation (in-person versus video-DOT), comparing individuals in the pre-COVID and COVID (April 2020) periods. Among 52 individuals with TB disease, 24 (46%) received treatment during the COVID-19 pandemic. vDOT utilization significantly increased in the COVID period (18/24[75%]) compared to pre-COVID (12/28[43%], p = 0.02). Overall, median verified adherence was similar pre-COVID and COVID periods (65% versus 68%, respectively, p = 0.96). Adherence was significantly higher overall when using vDOT (median 86% [IQR 70–98%]) compared to DOT (median 59% [IQR 55-64%], p < 0.01); this improved adherence with vDOT was evident in both the pre-COVID (median 98% vs. 58%, p < 0.01) and COVID period (median 80% vs. 62%, p = 0.01). vDOT utilization increased during the COVID period and was more effective than in-person DOT at verifying ingestion of prescribed treatment.
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DOI：
10.5588/ijtld.21.0170
发表时间：
2021-08-01
期刊：
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
影响因子：
--
作者：
Perry A;Chitnis A;Chin A;Hoffmann C;Chang L;Robinson M;Maltas G;Munk E;Shah M
通讯作者：
Shah M
影响因子：
11.8
作者：
Garfein, Richard S.;Liu, Lin;Raab, Fredric
通讯作者：
Raab, Fredric
影响因子：
11.8
作者：
Nahid, Payam;Dorman, Susan E.;Vernon, Andrew
通讯作者：
Vernon, Andrew
影响因子：
8.4
作者：
Karumbi, Jamlick;Garner, Paul
通讯作者：
Garner, Paul
影响因子：
158.5
作者：
Shah, Maunank;Dorman, Susan E.
通讯作者：
Dorman, Susan E.