Male Infertility and Oxidative Stress: A Focus on the Underlying Mechanisms.
Male Infertility and Oxidative Stress: A Focus on the Underlying Mechanisms.
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DOI：
10.3390/antiox11020306
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发表时间：
2022-02-02
期刊：
影响因子：
--
通讯作者：
Gharagozloo P
中科院分区：
文献类型：
--
作者：
Aitken RJ;Drevet JR;Moazamian A;Gharagozloo P
活性氧（ROS）在人类精子的功能能力中起着至关重要的作用。当产生适量时，ROS通过促进胆固醇从质膜流出、增强cAMP生成、诱导细胞质碱化、增加细胞内钙水平和刺激驱动获得能态的蛋白质磷酸化事件来促进精子获能。然而，当ROS生成过多和/或生殖系统的抗氧化防御受损时，可能会诱导氧化应激状态，从而破坏精子的受精能力和DNA的结构完整性。这篇文章的重点是ROS的来源在这个系统和检查的情况下，抗氧化保护的充分性可能成为一个限制因素。精子白细胞污染可导致射精中的氧化应激，而在种系中，精子线粒体中电子传输的失调、NADPH氧化酶活性的升高或氨基酸氧化酶作用的过度刺激都是氧化应激的潜在因素。了解在人类射精中产生这种压力的机制是必不可少的，以便开发更好的抗氧化策略，避免无意中产生其还原性对应物。
Reactive oxygen species (ROS) play a critical role in defining the functional competence of human spermatozoa. When generated in moderate amounts, ROS promote sperm capacitation by facilitating cholesterol efflux from the plasma membrane, enhancing cAMP generation, inducing cytoplasmic alkalinization, increasing intracellular calcium levels, and stimulating the protein phosphorylation events that drive the attainment of a capacitated state. However, when ROS generation is excessive and/or the antioxidant defences of the reproductive system are compromised, a state of oxidative stress may be induced that disrupts the fertilizing capacity of the spermatozoa and the structural integrity of their DNA. This article focusses on the sources of ROS within this system and examines the circumstances under which the adequacy of antioxidant protection might become a limiting factor. Seminal leukocyte contamination can contribute to oxidative stress in the ejaculate while, in the germ line, the dysregulation of electron transport in the sperm mitochondria, elevated NADPH oxidase activity, or the excessive stimulation of amino acid oxidase action are all potential contributors to oxidative stress. A knowledge of the mechanisms responsible for creating such stress within the human ejaculate is essential in order to develop better antioxidant strategies that avoid the unintentional creation of its reductive counterpart.
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影响因子：
5.2
作者：
Aitken RJ;Baker MA
通讯作者：
Baker MA
影响因子：
5.8
作者：
Aitken, R. J.;Muscio, L.;De Iuliis, G. N.
通讯作者：
De Iuliis, G. N.
影响因子：
3.6
作者：
Aitken, Joanna B.;Naumovski, Nenad;Aitken, R. John
通讯作者：
Aitken, R. John
影响因子：
6.1
作者：
AITKEN, RJ;BUCKINGHAM, DW;IRVINE, DS
通讯作者：
IRVINE, DS
影响因子：
3.6
作者：
Aitken, RJ;Gordon, E;Irvine, DS
通讯作者：
Irvine, DS