Dual-stimuli-responsive microparticles.
Dual-stimuli-responsive microparticles.
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DOI：
10.1021/acsami.5b01592
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发表时间：
2015-05-13
影响因子：
9.5
通讯作者：
Lahann J
中科院分区：
文献类型：
--
作者：
Sokolovskaya E;Rahmani S;Misra AC;Bräse S;Lahann J
生物技术领域对智能材料的需求推动了许多刺激响应聚合物的发展。这些聚合物中的许多对pH、光、温度或氧化应激有反应，但很少对多种刺激有反应。在这里，我们报告一种新的双刺激响应聚（乙二醇）为基础的聚合物的合成，能够改变其亲水性与紫外线（外源性刺激）和氧化应激（内源性刺激）的标志物治疗后。从这种聚合物，智能微粒和纤维制造和他们的反应，无论是刺激单独和联合进行了检查。降解动力学的比较表明，该聚合物成为水溶性后，只有在氧化和紫外光照射，这导致相应的颗粒的选择性降解。此外，体外实验证明这些颗粒被Raw 264.7细胞成功摄取。这种双刺激响应颗粒可能在药物输送、成像和组织工程中具有潜在的应用。
The need for smart materials in the area of biotechnology has fueled the development of numerous stimuli-responsive polymers. Many of these polymers are responsive to pH, light, temperature, or oxidative stress, and yet very few are responsive toward multiple stimuli. Here we report on the synthesis of a novel dual-stimuli-responsive poly(ethylene glycol)-based polymer capable of changing its hydrophilic properties upon treatment with UV light (exogenous stimulus) and markers of oxidative stress (endogenous stimulus). From this polymer, smart microparticles and fibers were fabricated and their responses to either stimulus separately and in conjunction were examined. Comparison of the degradation kinetics demonstrated that the polymer became water-soluble only after both oxidation and irradiation with UV light, which resulted in selective degradation of the corresponding particles. Furthermore, in vitro experiments demonstrated successful uptake of these particles by Raw 264.7 cells. Such dual-stimuli-responsive particles could have potential applications in drug delivery, imaging, and tissue engineering.
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影响因子：
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