Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses.
Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses.
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DOI：
10.1126/science.1225416
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发表时间：
2012-07-13
期刊：
影响因子：
--
通讯作者：
Wilson IA
中科院分区：
文献类型：
--
作者：
Burton DR;Poignard P;Stanfield RL;Wilson IA
某些人类病原体通过快速突变抗体反应所针对的表面抗原蛋白位点来避免被我们的免疫系统消除，因此它们往往对疫苗开发难以奏效。所描述的行为在包括艾滋病毒、流感和丙型肝炎病毒在内的病毒子集--高度抗原性多样化的病毒--中尤为突出。然而，这些病毒确实有高度保守的暴露部位，通常与功能有关，可以被广泛的中和抗体靶向。直到最近，已知的此类抗体并不多，但该领域的进步使越来越多的抗体得以识别。抗体的分子特征，以及最重要的是它们识别的脆弱部位的分子特征，为发现新的疫苗和药物带来了希望。
Certain human pathogens avoid elimination by our immune system by rapidly mutating the surface antigen protein sites targeted by antibody responses and consequently they tend to be refractory to vaccine development. The behavior described is prominent for a subset of viruses-the highly antigenically diverse viruses-which include HIV, influenza and hepatitis C viruses. However, these viruses do harbor highly conserved exposed sites, usually associated with function, which can be targeted by broadly neutralizing antibodies. Until recently, not many such antibodies were known but advances in the field have enabled increasing numbers to be identified. Molecular characterization of the antibodies and, most importantly, of the sites of vulnerability that they recognize, gives hope for the discovery of new vaccines and drugs.
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影响因子：
3.7
作者：
Corti D;Langedijk JP;Hinz A;Seaman MS;Vanzetta F;Fernandez-Rodriguez BM;Silacci C;Pinna D;Jarrossay D;Balla-Jhagjhoorsingh S;Willems B;Zekveld MJ;Dreja H;O'Sullivan E;Pade C;Orkin C;Jeffs SA;Montefiori DC;Davis D;Weissenhorn W;McKnight A;Heeney JL;Sallusto F;Sattentau QJ;Weiss RA;Lanzavecchia A
通讯作者：
Lanzavecchia A
影响因子：
5.6
作者：
Cardoso, Rosa M. F.;Brunel, Florence M.;Wilson, Ian A.
通讯作者：
Wilson, Ian A.
影响因子：
56.9
作者：
BURTON, DR;PYATI, J;BARBAS, CF
通讯作者：
BARBAS, CF
影响因子：
64.8
作者：
Balazs, Alejandro B.;Chen, Joyce;Hong, Christin M.;Rao, Dinesh S.;Yang, Lili;Baltimore, David
通讯作者：
Baltimore, David
DOI：
10.1126/science.1213782
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Diskin R;Scheid JF;Marcovecchio PM;West AP Jr;Klein F;Gao H;Gnanapragasam PN;Abadir A;Seaman MS;Nussenzweig MC;Bjorkman PJ
通讯作者：
Bjorkman PJ