Role of Transforming Growth Factor-β1 in Regulating Fetal-Maternal Immune Tolerance in Normal and Pathological Pregnancy.
Role of Transforming Growth Factor-β1 in Regulating Fetal-Maternal Immune Tolerance in Normal and Pathological Pregnancy.
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转化生长因子-β1在正常及病理妊娠中调节母胎免疫耐受的作用
DOI：
10.3389/fimmu.2021.689181
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发表时间：
2021
影响因子：
7.3
通讯作者：
Cheng Y
中科院分区：
文献类型：
--
作者：
Yang D;Dai F;Yuan M;Zheng Y;Liu S;Deng Z;Tan W;Chen L;Zhang Q;Zhao X;Cheng Y
Transforming growth factor-β (TGF-β) is composed of three isoforms, TGF-β1, TGF-β2, and TGF-β3. TGF-β1 is a cytokine with multiple biological functions that has been studied extensively. It plays an important role in regulating the differentiation of immune cells and maintaining immune cell functions and immune homeostasis. Pregnancy is a carefully regulated process. Controlled invasion of trophoblasts, precise coordination of immune cells and cytokines, and crosstalk between trophoblasts and immune cells play vital roles in the establishment and maintenance of normal pregnancy. In this systematic review, we summarize the role of TGF-β1 in regulating fetal-maternal immune tolerance in healthy and pathological pregnancies. During healthy pregnancy, TGF-β1 induces the production of regulatory T cells (Tregs), maintains the immunosuppressive function of Tregs, mediates the balance of M1/M2 macrophages, and regulates the function of NK cells, thus participating in maintaining fetal-maternal immune tolerance. In addition, some studies have shown that TGF-β1 is dysregulated in patients with recurrent spontaneous abortion or preeclampsia. TGF-β1 may play a role in the occurrence and development of these diseases and may be a potential target for the treatment of these diseases.
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影响因子：
8
作者：
通讯作者：
--
影响因子：
32.4
作者：
Fontenot, JD;Rasmussen, JP;Rudensky, AY
通讯作者：
Rudensky, AY
影响因子：
17.1
作者：
Cuende, Julia;Lienart, Stephanie;Lucas, Sophie
通讯作者：
Lucas, Sophie
影响因子：
7.5
作者：
Cen, Shuizhong;Wang, Peng;Wu, Yanfeng
通讯作者：
Wu, Yanfeng
影响因子：
6.1
作者：
CLARK, DA;VINCE, G;STARKEY, P
通讯作者：
STARKEY, P