The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice.
The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice.
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DOI：
10.3390/ijms222111383
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发表时间：
2021-10-21
影响因子：
5.6
通讯作者：
Lu YW
中科院分区：
文献类型：
--
作者：
Chang GR;Lin WL;Lin TC;Liao HJ;Lu YW
肝脏疾病是一个主要的健康问题。柴胡皂苷-d(SSD)是从中草药柴胡中提取的一种有效活性成分，具有抗炎、抗氧化等作用。然而，其保肝作用及其机制尚不清楚。探讨SSD对硫代乙酰胺(TAA)诱导的小鼠肝损伤和高脂饮食(HFD)诱导的非酒精性脂肪性肝病(NAFLD)的治疗作用及其机制。与对照组相比，SSD组大鼠摄食量、体重、肝脏抗氧化酶(过氧化氢酶、谷胱甘肽过氧化物酶、超氧化物歧化酶)显著增加，而肝脏环氧合酶-2、血清丙氨酸氨基转移酶、天冬氨酸氨基转移酶、碱性磷酸酶、白介素1β、肿瘤坏死因子-α和成纤维细胞生长因子-21表达降低，炎症相关基因(核因子-κB和诱导型一氧化氮合酶)表达降低。在非酒精性脂肪性肝病小鼠中，SSD可降低血清ALT、AST、甘油三酯、脂肪酸结合蛋白4(FABP 4)和固醇调节元件结合蛋白1(SREBP1mRNA)以及内质网应激相关蛋白(磷酸化真核细胞起始因子2α亚单位(p-eIF2α)、激活转录因子4(ATF4)和C/EBP同源蛋白(CHOP)。SSD通过抑制炎症反应和抗氧化剂的作用，在肝脏损伤中起到保护肝脏的作用。
Liver disorders are a major health concern. Saikosaponin-d (SSd) is an effective active ingredient extracted from Bupleurum falcatum, a traditional Chinese medicinal plant, with anti-inflammatory and antioxidant properties. However, its hepatoprotective properties and underlying mechanisms are unknown. We investigated the effects and underlying mechanisms of SSd treatment for thioacetamide (TAA)-induced liver injury and high-fat-diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) in male C57BL/6 mice. The SSd group showed significantly higher food intake, body weight, and hepatic antioxidative enzymes (catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD)) and lower hepatic cyclooxygenase-2 (COX-2), serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and fibroblast growth factor-21 (FGF21) compared with controls, as well as reduced expression of inflammation-related genes (nuclear factor kappa B (NF-κB) and inducible nitric oxide synthase (iNOS)) messenger RNA (mRNA). In NAFLD mice, SSd reduced serum ALT, AST, triglycerides, fatty acid–binding protein 4 (FABP4) and sterol regulatory element–binding protein 1 (SREBP1) mRNA, and endoplasmic reticulum (ER)-stress-related proteins (phosphorylated eukaryotic initiation factor 2α subunit (p-eIF2α), activating transcription factor 4 (ATF4), and C/EBP homologous protein (CHOP). SSd has a hepatoprotective effect in liver injury by suppressing inflammatory responses and acting as an antioxidant.
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DOI：
10.1016/j.jss.2009.10.006
发表时间：
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期刊：
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影响因子：
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