Shaping of the tumor microenvironment: Stromal cells and vessels.
Shaping of the tumor microenvironment: Stromal cells and vessels.
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DOI：
10.1016/j.semcancer.2015.03.002
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发表时间：
2015-10
影响因子：
14.5
通讯作者：
Vega F
中科院分区：
文献类型：
--
作者：
Blonska M;Agarwal NK;Vega F
淋巴瘤在专门的组织微环境如骨髓以及次级淋巴器官如淋巴结和脾中发展和进展。淋巴瘤微环境的特征在于基质细胞的异质群体，包括成纤维细胞网状细胞、乳样细胞、间充质干细胞、滤泡树突细胞和炎性细胞如巨噬细胞、T细胞和B细胞。这些细胞群与淋巴瘤细胞相互作用，通过多种机制促进淋巴瘤生长，存活和耐药性。血管生成也被认为是与淋巴瘤进展相关的重要因素。近年来，我们已经了解到恶性和非恶性细胞之间的相互作用是双向的，并且至少部分地类似于非肿瘤淋巴细胞和淋巴器官的正常微环境之间的模式。淋巴瘤微环境的细胞成分集中的当前知识的总结将在这里进行审查。
Lymphomas develop and progress in a specialized tissue microenvironment such as bone marrow as well as secondary lymphoid organs such as lymph node and spleen. The lymphoma microenvironment is characterized by a heterogeneous population of stromal cells, including fibroblastic reticular cells, nurse-like cells, mesenchymal stem cells, follicular dendritic cells, and inflammatory cells such as macrophages, T- and B-cells. These cell populations interact with the lymphoma cells to promote lymphoma growth, survival and drug resistance through multiple mechanisms. Angiogenesis is also recognized as an important factor associated with lymphoma progression. In recent years, we have learned that the interaction between the malignant and non-malignant cells is bidirectional and resembles, at least in part, the pattern seen between non-neoplastic lymphoid cells and the normal microenvironment of lymphoid organs. A summary of the current knowledge of lymphoma microenvironment focusing on the cellular components will be reviewed here.
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影响因子：
20.3
作者：
Carreras, Joaquim;Lopez-Guillermo, Armando;Banham, Alison H.
通讯作者：
Banham, Alison H.
影响因子：
4.8
作者：
Agarwal, Nitin K.;Qu, Changju;Vega, Francisco
通讯作者：
Vega, Francisco
DOI：
10.3324/haematol.2010.037408
发表时间：
2011-07-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Cardesa-Salzmann, Teresa M.;Colomo, Luis;Campo, Elias
通讯作者：
Campo, Elias
影响因子：
64.8
作者：
Compagno, Mara;Lim, Wei Keat;Grunn, Adina;Nandula, Subhadra V.;Brahmachary, Manisha;Shen, Qiong;Bertoni, Francesco;Ponzoni, Maurilio;Scandurra, Marta;Califano, Andrea;Bhagat, Govind;Chadburn, Amy;Dalla-Favera, Riccardo;Pasqualucci, Laura
通讯作者：
Pasqualucci, Laura
影响因子：
2.6
作者：
Byrd, John C.;Kipps, Thomas J.;O'Brien, Susan
通讯作者：
O'Brien, Susan