Limb segment vibration modulates spinal reflex excitability and muscle mRNA expression after spinal cord injury.
Limb segment vibration modulates spinal reflex excitability and muscle mRNA expression after spinal cord injury.
复制标题
肢体振动调节脊髓损伤后脊柱反射兴奋性和肌肉mRNA表达。
DOI：
10.1016/j.clinph.2011.08.001
复制
发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Shields RK
中科院分区：
文献类型：
--
作者：
Chang SH;Tseng SC;McHenry CL;Littmann AE;Suneja M;Shields RK
我们研究了不同剂量的垂直振荡（振动）对有或没有 SCI 个体的比目鱼肌 H 反射幅度和激活后抑郁的影响。我们还探讨了短期肢体振动对与脊柱可塑性相关的骨骼肌 mRNA 表达的急性影响。六名健康成年人和五名慢性完全性 SCI 受试者的胫骨接受固定频率 (30 Hz) 三种不同重力加速度（0.3g、0.6g 和 1.2g）的振动刺激。在振动之前、期间和之后测量比目鱼肌 H 反射。另外两名慢性完全性 SCI 受试者在单次振动后 3 小时进行了比目鱼肌活检。在振动过程中，两组的 H 反射幅度均降低了 83% 以上。这种振动诱导的抑制在对照组中持续超过 2 分钟，但在 SCI 组中则不然。激活后抑制在长期振动抑制过程中受到调节。单次机械振动改变了与突触可塑性相关的选定基因的 mRNA 表达。小腿的振动会抑制 H 反射幅度，影响激活后抑制，并改变与突触可塑性相关的基因的骨骼肌 mRNA 表达。肢体节段振动可能是减少 SCI 后脊髓反射兴奋性的长期方法。
We investigated the effect of various doses of vertical oscillation (vibration) on soleus H-reflex amplitude and post-activation depression in individuals with and without SCI. We also explored the acute effect of short-term limb vibration on skeletal muscle mRNA expression of genes associated with spinal plasticity. Six healthy adults and five chronic complete SCI subjects received vibratory stimulation of their tibia over three different gravitational accelerations (0.3g, 0.6g, and 1.2g) at a fixed frequency (30 Hz). Soleus H-reflexes were measured before, during, and after vibration. Two additional chronic complete SCI subjects had soleus muscle biopsies 3 h following a single bout of vibration. H-reflex amplitude was depressed over 83% in both groups during vibration. This vibratory-induced inhibition lasted over 2 min in the control group, but not in the SCI group. Post-activation depression was modulated during the long-lasting vibratory inhibition. A single bout of mechanical oscillation altered mRNA expression from selected genes associated with synaptic plasticity. Vibration of the lower leg inhibits the H-reflex amplitude, influences post-activation depression, and alters skeletal muscle mRNA expression of genes associated with synaptic plasticity. Limb segment vibration may offer a long term method to reduce spinal reflex excitability after SCI.
登录
查看更多内容
影响因子：
5.5
作者：
FROMM, C;NOTH, J
通讯作者：
NOTH, J
影响因子：
2
作者：
Grey, Michael J.;Klinge, Klaus;Nielsen, Jens B.
通讯作者：
Nielsen, Jens B.
影响因子：
11
作者：
DEGAIL, P;LANCE, JW;NEILSON, PD
通讯作者：
NEILSON, PD
影响因子：
5.3
作者：
Feng, J;Chi, P;Greengard, P
通讯作者：
Greengard, P
DOI：
10.1016/0168-5597(93)90131-8
发表时间：
1993-06-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
CALANCIE, B;BROTON, JG;AYYAR, DR
通讯作者：
AYYAR, DR