Reassortment patterns in Swine influenza viruses.
Reassortment patterns in Swine influenza viruses.
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DOI：
10.1371/journal.pone.0007366
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发表时间：
2009-10-07
期刊：
影响因子：
3.7
通讯作者：
Rabadan R
中科院分区：
文献类型：
--
作者：
Khiabanian H;Trifonov V;Rabadan R
世纪发生了三次人类流感大流行，分别是1918年、1957年和1968年。流感大流行毒株是来自非人类宿主的新出现病毒的结果，人类对这些病毒几乎没有免疫力。在1957年和1968年发生的两次大流行中，至少有两次是人类和鸟类病毒之间的重新组合。此外，据报道，许多猪流感病毒感染了人类，特别是最近在墨西哥和美国分离出的猪源H1N1流感病毒。据记载，猪允许人、禽和猪流感病毒的生产性复制。因此，猪被认为是产生禽-人流感病毒株的“混合容器”，导致了人类大流行。因此，研究病毒重组的过程和模式，特别是在猪中，是更好地了解人类流感大流行的关键。在过去的几年里，包含自1918年以来从不同地理位置收集的甲型流感病毒（包括猪病毒）序列的数据库已经开发并公开提供。在本文中，我们研究了一个合奏的猪流感病毒的重组现象，通过几种统计技术进行分析。在猪病毒中的重配模式被证明是相似的，在人类病毒中发现的，在体外和体内，表面糖蛋白编码段最经常的重配。此外，我们发现，聚合酶节段之一（PB 1），重新排列的菌株负责最后两个人类大流行病，也经常recruits。
Three human influenza pandemics occurred in the twentieth century, in 1918, 1957, and 1968. Influenza pandemic strains are the results of emerging viruses from non-human reservoirs to which humans have little or no immunity. At least two of these pandemic strains, in 1957 and in 1968, were the results of reassortments between human and avian viruses. Also, many cases of swine influenza viruses have reportedly infected humans, in particular, the recent H1N1 influenza virus of swine origin, isolated in Mexico and the United States. Pigs are documented to allow productive replication of human, avian, and swine influenza viruses. Thus it has been conjectured that pigs are the “mixing vessel” that create the avian-human reassortant strains, causing the human pandemics. Hence, studying the process and patterns of viral reassortment, especially in pigs, is a key to better understanding of human influenza pandemics. In the last few years, databases containing sequences of influenza A viruses, including swine viruses, collected since 1918 from diverse geographical locations, have been developed and made publicly available. In this paper, we study an ensemble of swine influenza viruses to analyze the reassortment phenomena through several statistical techniques. The reassortment patterns in swine viruses prove to be similar to the previous results found in human viruses, both in vitro and in vivo, that the surface glycoprotein coding segments reassort most often. Moreover, we find that one of the polymerase segments (PB1), reassorted in the strains responsible for the last two human pandemics, also reassorts frequently.
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