Charged Metallopolymer-Grafted Silica Nanoparticles for Antimicrobial Applications.
Charged Metallopolymer-Grafted Silica Nanoparticles for Antimicrobial Applications.
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DOI：
10.1021/acs.biomac.7b01510
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发表时间：
2018-02-12
影响因子：
6.2
通讯作者：
Tang C
中科院分区：
文献类型：
--
作者：
Pageni P;Yang P;Chen YP;Huang Y;Bam M;Zhu T;Nagarkatti M;Benicewicz BC;Decho AW;Tang C
抗生素的不适当和频繁使用导致了抗药性细菌的发展，这种细菌会导致难以治疗的传染病。随着抗生素耐药性威胁的不断增加，开发有效的新抗菌剂的必要性日益突出。我们报道了由二氧化硅纳米粒子表面引发的含钴甲基丙烯酸酯单体的表面引发可逆加成-断裂链转移聚合制备的抗菌金属聚合物纳米粒子。这些微粒能够与青霉素等β-内酰胺类抗生素形成复合体，使抗生素的杀菌活性恢复活力。纸片扩散法显示对革兰氏阳性菌和革兰氏阴性菌的抗菌活性均显著增强。效率的提高归因于抑制了β-内酰胺类抗生素的水解和提高了纳米颗粒表面的局部抗生素浓度。此外，溶血评估显示对红细胞的毒性最小。
Inappropriate and frequent use of antibiotics has led to the development of antibiotic-resistant bacteria, which cause infectious diseases that are difficult to treat. With the rising threat of antibiotic resistance, the need to develop effective new antimicrobial agents is prominent. We report antimicrobial metallopolymer nanoparticles, which were prepared by surface-initiated reversible addition–fragmentation chain transfer polymerization of a cobaltocenium-containing methacrylate monomer from silica nanoparticles. These particles are capable of forming a complex with β-lactam antibiotics, such as penicillin, rejuvenating the bactericidal activity of the antibiotic. Disk diffusion assays showed significantly increased antibacterial activities against both Gram-positive and Gram-negative bacteria. The improved efficiencies were attributed to the inhibition of hydrolysis of the β-lactam antibiotics and enhancement of local antibiotics concentration on a nanoparticle surface. In addition, hemolysis evaluations demonstrated minimal toxicity to red blood cells.
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影响因子：
15
作者：
Kim, Sung Hoon;Jeyakumar, M.;Katzenellenbogen, John A.
通讯作者：
Katzenellenbogen, John A.
影响因子：
17.1
作者：
Li, Xiaoning;Robinson, Sandra M.;Gupta, Akash;Saha, Krishnendu;Jiang, Ziwen;Moyano, Daniel F.;Sahar, Ali;Riley, Margaret A.;Rotello, Vincent M.
通讯作者：
Rotello, Vincent M.
影响因子：
3.9
作者：
Kang, Seoktae;Herzberg, Moshe;Elimelech, Menachem
通讯作者：
Elimelech, Menachem
影响因子：
13.3
作者：
Chen, Hanqing;Wang, Bing;Feng, Weiyue
通讯作者：
Feng, Weiyue
影响因子：
46.2
作者：
Elsabahy M;Wooley KL
通讯作者：
Wooley KL