Evolution of the Long Non-coding RNAs MALAT1 and MENbeta/epsilon

Evolution of the Long Non-coding RNAs MALAT1 and MENbeta/epsilon
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长非编码 RNA MALAT1 和 MENbeta/epsilon 的进化

DOI:
10.1007/978-3-642-15060-9_1
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发表时间:
2010
期刊:
影响因子:
4.3
通讯作者:
P. Stadler
P. Stadler
中科院分区:
生物学3区
文献类型:
--
作者:
P. Stadler

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β1是哺乳动物中最保守的长ncRNA之一,它有几个特征,其中包括核保留和其3‘端的非标准加工,相邻的男性MALAT1 RNA较长,但保守程度较低。我们发现MALAT1在脊椎动物中是保守的(鸟类可能是例外),而人类β可能起源于哺乳动物的干细胞谱系。讨论了这两种转录本的进化保守特征,包括RNA二级结构基序和短RNA加工产物。
MALAT1 is one of the best-conserved long ncRNAs in mammals and shares several characteristics, among them nuclear retention and a non-standard processing of its 3' end, with the longer, but less well conserved, adjacent MENβ RNA. We show that MALAT1 is conserved among gnathostomes (with the possible exception of birds), while MENβ likely originated in the mammalian stem lineage. Evolutionary conserved features of both transcripts are discussed, including RNA secondary structure motifs and short RNA processing products.
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