Evolution of the Long Non-coding RNAs MALAT1 and MENbeta/epsilon
Evolution of the Long Non-coding RNAs MALAT1 and MENbeta/epsilon
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长非编码 RNA MALAT1 和 MENbeta/epsilon 的进化
DOI:
10.1007/978-3-642-15060-9_1
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发表时间:
2010
期刊:
影响因子:
4.3
通讯作者:
P. Stadler
中科院分区:
文献类型:
--
作者:
P. Stadler
MALAT1 is one of the best-conserved long ncRNAs in mammals and shares several characteristics, among them nuclear retention and a non-standard processing of its 3' end, with the longer, but less well conserved, adjacent MENβ RNA. We show that MALAT1 is conserved among gnathostomes (with the possible exception of birds), while MENβ likely originated in the mammalian stem lineage. Evolutionary conserved features of both transcripts are discussed, including RNA secondary structure motifs and short RNA processing products.
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