Potential risk factors for reactive arthritis and persistence of symptoms at 2 years: a case-control study with longitudinal follow-up.
Potential risk factors for reactive arthritis and persistence of symptoms at 2 years: a case-control study with longitudinal follow-up.
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反应性关节炎的潜在危险因素和2年症状的持久性：一项纵向随访的病例对照研究。
DOI：
10.1007/s10067-017-3911-3
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发表时间：
2018-03
影响因子：
3.4
通讯作者：
Ogdie A
中科院分区：
文献类型：
--
作者：
Garcia Ferrer HR;Azan A;Iraheta I;Von Feldt J;Espinoza LR;Manasson J;Scher JU;Garcia Kutzbach A;Ogdie A
确定发生反应性关节炎（ReA）的危险因素，并检查与症状持续相关的因素。在危地马拉城前瞻性入组了在研究入组前3-6个月内新诊断为ReA的患者和患有胃肠道（GI）、泌尿生殖道或性传播感染的对照患者。ReA患者符合ASAS外周脊柱关节病（SpA）标准。患者接受病史、检查、跟腱超声和抽血。测量人类白细胞抗原（HLA）分型和血清生物标志物。使用T检验和非参数等效方法来检查临床、实验室和成像因素与ReA的相关性。2年后联系患者以评估症状的持续性。研究受试者包括ReA患者（N=32）和对照组（N=32）。ReA患者最常在4月感染，而对照组最常在8月感染。2例ReA患者和2例对照HLA-B27阳性。与对照组相比，ReA患者的血清组织蛋白酶K和C反应蛋白较高（两者均为P = 0.03），而总胆固醇和低密度脂蛋白较低（分别为P=0.008和0.045）。在ReA患者中，15例（47%）患者在2年时仍有症状。这些患者在诊断时的基质金属蛋白酶-3水平低于ReA消退的患者（p=0.004）。在危地马拉，HLA-B27与ReA的发展无关，然而，感染月份与ReA相关。最引人注目的发现是近一半的患者在2年时关节炎持续存在。
To determine risk factors for the development of reactive arthritis (ReA) and examine factors associated with persistence of symptoms. Patients with a new diagnosis of ReA and controls with a gastrointestinal (GI), urogenital, or sexually transmitted infection in the 3–6 months prior to study entry were prospectively enrolled in Guatemala City. ReA patients fulfilled ASAS criteria for peripheral spondyloarthropathy (SpA). Patients underwent history, examination, Achilles tendon ultrasound, and blood draw. Human leukocyte antigen (HLA) type and serum biomarkers were measured. T-tests and nonparametric equivalents were used to examine the association of clinical, laboratory, and imaging factors with ReA. Patients were contacted 2 years later to assess for persistence of symptoms. Study subjects included patients with ReA (N=32) and controls (N=32). ReA patients were most frequently infected in April whereas controls were most frequently infected in August. Two ReA patients and two controls were HLA-B27 positive. Serum cathepsin K and C-reactive protein were higher in ReA patients compared to controls (P = 0.03 for both), while total cholesterol and low density lipoprotein were lower (p=0.008 and 0.045 respectively). Among those with ReA, 15 (47%) patients had continued symptoms at 2 years. These patients had a lower matrix metalloproteinase-3 level at diagnosis than patients for whom ReA resolved (p=0.004). HLA-B27 was not associated with development of ReA in Guatemala, however, month of infection was associated with ReA. The most striking finding was the persistence of arthritis at 2 years in nearly half of patients.
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影响因子：
3.4
作者：
Reveille, John D.
通讯作者：
Reveille, John D.
DOI：
10.1016/j.berh.2006.03.007
发表时间：
2006-06-01
影响因子：
5.2
作者：
D'Agostino, Maria Antonietta;Olivieri, Ignazio
通讯作者：
Olivieri, Ignazio
影响因子：
13.3
作者：
Baillet, Athan C.;Rehaume, Linda M.;Thomas, Ranjeny
通讯作者：
Thomas, Ranjeny
影响因子：
27.4
作者：
Rudwaleit, M.;van der Heijde, D.;Sieper, J.
通讯作者：
Sieper, J.
DOI：
10.1038/nrrheum.2011.121
发表时间：
2011-08-23
期刊：
Nature reviews. Rheumatology
影响因子：
--
作者：
通讯作者：
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