Immunological control of herpes simplex virus infections.
Immunological control of herpes simplex virus infections.
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DOI：
10.1007/s13365-013-0189-3
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发表时间：
2013-08
影响因子：
3.2
通讯作者：
Jennings, Stephen R.
中科院分区：
文献类型：
--
作者：
Egan, Kevin P.;Wu, Sharon;Wigdahl, Brian;Jennings, Stephen R.
关键词：
单纯疱疹病毒1型（HSV-1）能够在感觉神经元中引起潜伏感染，持续宿主的一生。原发性感染在诱导控制病毒复制的先天免疫应答后消退，直到适应性免疫应答可以清除活动性感染。HSV-1特异性CD 8 + T细胞探查含有潜伏感染的神经元的神经节区域，并参与防止HSV从潜伏期再激活。三叉神经节中T细胞的长期驻留和迁移动力学似乎将它们与传统的记忆T细胞亚群区分开来。最近描述的组织驻留记忆（TRM）T细胞在抗原暴露后在外周组织隔室中建立驻留并长期存活。本文综述了免疫系统对HSV-1感染的反应。特别强调的证据指向HSV-1特异性的CD 8 + T细胞在三叉神经属于TRM类记忆T细胞和TRM细胞在病毒感染，发病机制，潜伏期和疾病的作用。
Herpes simplex virus type 1 (HSV-1) is capable of causing a latent infection in sensory neurons that lasts for the lifetime of the host. The primary infection is resolved following the induction of the innate immune response that controls replication of the virus until the adaptive immune response can clear the active infection. HSV-1-specific CD8+ T cells survey the ganglionic regions containing latently infected neurons and participate in preventing reactivation of HSV from latency. The long-term residence and migration dynamics of the T cells in the trigeminal ganglia appear to distinguish them from the traditional memory T cell subsets. Recently described tissue resident memory (TRM) T cells establish residence and survive for long periods in peripheral tissue compartments following antigen exposure. This review focuses on the immune system response to HSV-1 infection. Particular emphasis is placed on the evidence pointing to the HSV-1-specific CD8+ T cells in the trigeminal belonging to the TRM class of memory T cells and the role of TRM cells in virus infection, pathogenesis, latency, and disease.
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