Recurrent Hippocampo-neocortical sleep-state divergence in humans.
Recurrent Hippocampo-neocortical sleep-state divergence in humans.
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DOI：
10.1073/pnas.2123427119
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发表时间：
2022-11
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
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作者：
我们在这里报告的证据表明，人类皮层和皮层下的大脑区域存在于不同的组合，同时睡眠-觉醒状态在整个晚上。这些发现有助于我们理解产生睡眠的机制的复杂性，并对睡眠的功能产生影响。未来的研究应该直接测量或考虑感兴趣区域的假定睡眠状态，否则就有可能错过对皮层下区域的实验操作的重要影响，而这些影响对理解手头的睡眠问题至关重要。睡眠被认为是人类和大多数其他动物的一个整体状态，由脑干、下丘脑和基底前脑的执行中心协调。然而，在鸟类和海洋哺乳动物中普遍观察到的半球睡眠，以及最近在啮齿动物中发现的非病理性区域睡眠，让人怀疑整个人类大脑是否也可能同时在大脑区域之间表现出不同的状态。我们分析了睡眠状态独立于同时记录的海马深度电极和皮层头皮电极在8个人类受试者植入深度电极难治性癫痫评估。我们发现，新皮层和海马体可能处于非同步状态，平均有三分之一的夜晚，海马体经常导致异步状态转换。非同时回合长度从30秒到超过30分钟不等。这些结果质疑了研究的结论，在整个胚胎发育过程中，只测量表面皮层状态，但试图评估整个大脑的睡眠状态的功能和驱动因素。
We report here evidence that human cortical and subcortical brain areas exist in different combinations of simultaneous sleep–wake states throughout the night. These findings contribute to our understanding of the complexity of the mechanisms generating sleep and hold implications for the functions of sleep. Future studies should directly measure or take into consideration the putative sleep state of the region of interest, or risk missing important effects of experimental manipulations on subcortical areas that could be critical to understanding the sleep question at hand. Sleep is assumed to be a unitary, global state in humans and most other animals that is coordinated by executive centers in the brain stem, hypothalamus, and basal forebrain. However, the common observation of unihemispheric sleep in birds and marine mammals, as well as the recently discovered nonpathological regional sleep in rodents, calls into question whether the whole human brain might also typically exhibit different states between brain areas at the same time. We analyzed sleep states independently from simultaneously recorded hippocampal depth electrodes and cortical scalp electrodes in eight human subjects who were implanted with depth electrodes for pharmacologically intractable epilepsy evaluation. We found that the neocortex and hippocampus could be in nonsimultaneous states, on average, one-third of the night and that the hippocampus often led in asynchronous state transitions. Nonsimultaneous bout lengths varied from 30 s to over 30 min. These results call into question the conclusions of studies, across phylogeny, that measure only surface cortical state but seek to assess the functions and drivers of sleep states throughout the brain.
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影响因子：
1.8
作者：
Frazer, Michelle A.;Cabrera, Yesenia;Poe, Gina R.
通讯作者：
Poe, Gina R.
影响因子：
4.4
作者：
Ermis, Ummehan;Krakow, Karsten;Voss, Ursula
通讯作者：
Voss, Ursula
影响因子：
4.4
作者：
Kato, T;Montplaisir, JY;Lavigne, GJ
通讯作者：
Lavigne, GJ
癫痫，认知和神经精神病学（癫痫，大脑和思想，第2部分）。
DOI：
10.1016/j.yebeh.2013.03.012
发表时间：
2013-08
期刊：
Epilepsy & behavior : E&B
影响因子：
--
作者：
Korczyn AD;Schachter SC;Brodie MJ;Dalal SS;Engel J Jr;Guekht A;Hecimovic H;Jerbi K;Kanner AM;Johannessen Landmark C;Mares P;Marusic P;Meletti S;Mula M;Patsalos PN;Reuber M;Ryvlin P;Štillová K;Tuchman R;Rektor I
通讯作者：
Rektor I
影响因子：
3.8
作者：
Esser, SK;Huber, R;Tononi, G
通讯作者：
Tononi, G